Approaches for Identifying Novel Targets in Precision Medicine: Lessons from DNA Repair.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-60733-7_1
Abstract: Genome stability is maintained by a number of elegant mechanisms, which sense and repair damaged DNA. Germline defects that compromise genomic integrity result in cancer predisposition, exemplified by rare syndromes caused by mutations in certain… read more here.
Keywords: medicine; dna repair; approaches identifying; novel targets ... See more keywords
A diagnosis of discernment: Identifying a novel ATRX mutation in myelodysplastic syndrome with acquired α-thalassemia.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer genetics"
DOI: 10.1016/j.cancergen.2019.01.002
Abstract: Myelodysplastic syndromes (MDS) are a heterogeneous category of myeloid neoplasms that represent the most common class of acquired bone marrow failure syndromes in adults. MDS is typically associated with a hypoproliferative macrocytic anemia, but atypical… read more here.
Keywords: novel atrx; discernment identifying; atrx mutation; identifying novel ... See more keywords
Identifying novel conopepetides from the venom ducts of Conus litteratus through integrating transcriptomics and proteomics.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of proteomics"
DOI: 10.1016/j.jprot.2018.09.015
Abstract: The venom ducts of marine cone snails secrete highly complex mixtures of cysteine-rich active peptides, which are generally known as conotoxins or conopeptides and provide a potential fertile resource for pharmacological neuroscience research and the… read more here.
Keywords: novel conopepetides; cone snails; proteomics identifying; identifying novel ... See more keywords
Sulfonanilide Derivatives in Identifying Novel Aromatase Inhibitors by Applying Docking, Virtual Screening, and MD Simulations Studies
Sign Up to like & getrecommendations! Published in 2017 at "BioMed Research International"
DOI: 10.1155/2017/2105610
Abstract: Breast cancer is one of the leading causes of death noticed in women across the world. Of late the most successful treatments rendered are the use of aromatase inhibitors (AIs). In the current study, a… read more here.
Keywords: sulfonanilide derivatives; aromatase inhibitors; novel aromatase; derivatives identifying ... See more keywords
Abstract LB062: Identifying novel targets for CAR-T therapies from single cell RNA-sequencing data
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-lb062
Abstract: Chimeric antigen receptor T (CAR-T) cell therapies have revolutionized cancer treatment. While CAR-T has yielded tremendous clinical success for patients with liquid tumors, its potential remains to be unleashed against solid tumors. One key challenge… read more here.
Keywords: cell; identifying novel; novel targets; car ... See more keywords
Abstract 5664: Identifying novel vulnerabilities in clear cell sarcoma through functional and genomic screening
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-5664
Abstract: Clear Cell Sarcoma (CCSA) is a rare soft tissue sarcoma characterized by specific gene fusions EWSR1::ATF1 or EWSR1::CREB1, leading to the expression of an oncogenic fusion protein. Metastasized CCSA is resistant to conventional chemotherapy, targeted… read more here.
Keywords: identifying novel; screening; cell sarcoma; cell ... See more keywords
Abstract B009: Identifying of a novel diagnostic markers for pancreatic neuroendocrine tumors by proteomics with patient blood
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.panca2023-b009
Abstract: Neuroendocrine tumors are tumors originating from endocrine cells in various organs, and present very heterogeneous characteristics, and the incidence rate is gradually increasing. Among them, neuroendocrine tumors originating from pancreas are divided into functional tumors… read more here.
Keywords: diagnosis; identifying novel; pancreatic neuroendocrine; pnet ... See more keywords
Genetic studies as a tool for identifying novel potential targets for treatment of COPD
Sign Up to like & getrecommendations! Published in 2017 at "European Respiratory Journal"
DOI: 10.1183/13993003.02042-2017
Abstract: Chronic obstructive pulmonary disease (COPD), characterised by chronic airflow limitation and abnormal response to noxious particles or gases [1], is currently the fourth leading cause of death worldwide [2] and the only major cause of… read more here.
Keywords: studies tool; treatment; copd; genetic studies ... See more keywords
MINTIE: identifying novel structural and splice variants in transcriptomes using RNA-seq data
Sign Up to like & getrecommendations! Published in 2021 at "Genome Biology"
DOI: 10.1186/s13059-021-02507-8
Abstract: Calling fusion genes from RNA-seq data is well established, but other transcriptional variants are difficult to detect using existing approaches. To identify all types of variants in transcriptomes we developed MINTIE, an integrated pipeline for… read more here.
Keywords: variants transcriptomes; seq data; mintie identifying; identifying novel ... See more keywords
Identifying a novel class of lead compounds for monoacylglycerol lipase inhibition: an integrated computational study.
Sign Up to like & getrecommendations! Published in 2025 at "Cellular and molecular biology"
DOI: 10.14715/cmb/2025.71.5.14
Abstract: Monoacylglycerol lipase (MAGL) is a serine hydrolase that degrades the endocannabinoid 2-arachidonoylglycerol and other monoacylglycerols in the brain and peripheral tissues. Elevated MAGL levels in invasive malignancies promote tumor growth by releasing free fatty acids,… read more here.
Keywords: identifying novel; kcal mol; inhibition; monoacylglycerol lipase ... See more keywords
Identifying novel biomarkers associated with bladder cancer treatment outcomes
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1114203
Abstract: Bladder cancer is a complex disease with variable prognosis. Recent investigations into the molecular landscape of bladder cancer have revealed frequent genetic alterations and molecular subtypes with therapeutic implications. Consequently, a shift toward personalized treatment… read more here.
Keywords: novel biomarkers; identifying novel; treatment; bladder cancer ... See more keywords