Association of MGMT Promotor Methylation With Survival in Low-grade and Anaplastic Gliomas After Alkylating Chemotherapy.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2023.0990
Abstract: Importance O6-methylguanine-DNA methyltransferase (MGMT [OMIM 156569]) promoter methylation (mMGMT) is predictive of response to alkylating chemotherapy for glioblastomas and is routinely used to guide treatment decisions. However, the utility of MGMT promoter status for low-grade… read more here.
Keywords: gliomas; idh; alkylating chemotherapy; ahr ... See more keywords
Isocitrate dehydrogenase‐mutant glioma: Evolving clinical and therapeutic implications
Sign Up to like & getrecommendations! Published in 2017 at "Cancer"
DOI: 10.1002/cncr.31039
Abstract: The metabolic genes isocitrate dehydrogenase 1 (IDH1) and IDH2 are commonly mutated in low‐grade glioma and in a subset of glioblastoma. These mutations co‐occur with other recurrent molecular alterations, including 1p/19q codeletions and tumor suppressor… read more here.
Keywords: glioma; isocitrate dehydrogenase; idh; mutant glioma ... See more keywords
Integration of dynamic parameters in the analysis of 18F-FDopa PET imaging improves the prediction of molecular features of gliomas
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-019-04509-y
Abstract: 18F-FDopa PET imaging of gliomas is routinely interpreted with standardized uptake value (SUV)-derived indices. This study aimed to determine the added value of dynamic 18F-FDopa PET parameters for predicting the molecular features of newly diagnosed… read more here.
Keywords: 18f fdopa; gliomas; idh; fdopa pet ... See more keywords
Neuro research presentation sessions at ECR 2020
Sign Up to like & getrecommendations! Published in 2020 at "European Radiology"
DOI: 10.1007/s00330-020-06743-7
Abstract: The greatest novelties in the research presentation sessions (RPS) on neuroimaging at the European Congress of Radiology (ECR) 2020 are related to progress in advanced magnetic resonance imaging (MRI) techniques and artificial intelligence (AI). But,… read more here.
Keywords: presentation; research; ecr 2020; idh ... See more keywords
Static 18F-FET PET and DSC-PWI based on hybrid PET/MR for the prediction of gliomas defined by IDH and 1p/19q status
Sign Up to like & getrecommendations! Published in 2020 at "European Radiology"
DOI: 10.1007/s00330-020-07470-9
Abstract: To investigate the predictive value of static O-(2-18F-fluoroethyl)-L-tyrosine positron emission tomography (18F-FET PET) and cerebral blood volume (CBV) for glioma grading and determining isocitrate dehydrogenase (IDH) mutation and 1p/19q codeletion status. Fifty-two patients with newly… read more here.
Keywords: dsc pwi; pet; fet pet; idh ... See more keywords
Machine learning reveals multimodal MRI patterns predictive of isocitrate dehydrogenase and 1p/19q status in diffuse low- and high-grade gliomas
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-019-03096-0
Abstract: PurposeIsocitrate dehydrogenase (IDH) and 1p19q codeletion status are importantin providing prognostic information as well as prediction of treatment response in gliomas. Accurate determination of the IDH mutation status and 1p19q co-deletion prior to surgery may… read more here.
Keywords: status; dehydrogenase; machine learning; gliomas ... See more keywords
Contrast-enhancement in supratentorial low-grade gliomas: a classic prognostic factor in the molecular age
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-019-03183-2
Abstract: BackgroundContrast enhancement (CE) is found in 10–60% of low-grade gliomas. Its prognostic significance is controversial, and its correlation with IDH mutations and 1p/19q codeletion is elusive. The aim of this study is to investigate whether… read more here.
Keywords: gliomas; age; idh; grade gliomas ... See more keywords
Diffuse astrocytic glioma, IDH-Wildtype, with molecular features of glioblastoma, WHO grade IV: A single-institution case series and review
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-020-03677-4
Abstract: Objective In 2018, cIMPACT-NOW update 3 concluded that WHO grade II/III IDH-wildtype diffuse astrocytomas that contain TERT promoter mutations, chromosome 7 gain/10 loss, and/or EGFR amplification, correspond to a WHO grade IV diagnosis and should… read more here.
Keywords: diffuse astrocytic; institution; idh; idh wildtype ... See more keywords
Prediction of IDH Mutation Status in High-grade Gliomas Using DWI and High T1-weight DSC-MRI.
Sign Up to like & getrecommendations! Published in 2021 at "Academic radiology"
DOI: 10.1016/j.acra.2021.02.002
Abstract: RATIONALE AND OBJECTIVES We aimed to evaluate the diagnostic performance of diffusion-weighted imaging (DWI) and dynamic susceptibility contrast-enhanced (DSC) magnetic resonance imaging (MRI) parameters in the noninvasive prediction of the isocitrate dehydrogenase (IDH) mutation status… read more here.
Keywords: mutation status; idh mutation; mri; idh ... See more keywords
IDH-1 polymorphisms in pilocytic astrocytomas.
Sign Up to like & getrecommendations! Published in 2019 at "Annals of diagnostic pathology"
DOI: 10.1016/j.anndiagpath.2019.151411
Abstract: As of 2016, isocitrate dehydrogenase (IDH)-1 and IDH-2 mutations are part of the definition of an oligodendroglioma and may be seen in a significant subset of grade II-IV fibrillary astrocytomas. Reports of IDH-1 and IDH-2… read more here.
Keywords: polymorphisms pilocytic; idh; pilocytic astrocytomas; idh polymorphisms ... See more keywords
Relevance of calcification and contrast enhancement pattern for molecular diagnosis and survival prediction of gliomas based on the 2016 World Health Organization Classification
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Neurology and Neurosurgery"
DOI: 10.1016/j.clineuro.2019.105556
Abstract: OBJECTIVES The significance of conventional neuroimaging features for predicting molecular diagnosis and patient survival based on the updated World Health Organization (WHO) classification remains uncertain. We assessed the relevance of neuroimaging features (ring enhancement [RE],… read more here.
Keywords: gde; idh; enhancement; molecular diagnosis ... See more keywords