Intraoperative detection of IDH‐mutant glioma using fluorescence lifetime imaging
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biophotonics"
DOI: 10.1002/jbio.202200291
Abstract: Identifying isocitrate dehydrogenase (IDH)‐mutation and glioma subtype during surgery instead of days later can aid in modifying tumor resection strategies for better survival outcomes. We report intraoperative identification of IDH‐mutant glioma (N = 12 patients)… read more here.
Keywords: idh mutant; mutant glioma; glioma; fluorescence lifetime ... See more keywords
Loss of H3K27 trimethylation by immunohistochemistry is frequent in oligodendroglioma, IDH-mutant and 1p/19q-codeleted, but is neither a sensitive nor a specific marker
Sign Up to like & getrecommendations! Published in 2020 at "Acta Neuropathologica"
DOI: 10.1007/s00401-019-02123-8
Abstract: The integrated diagnosis for infiltrating gliomas requires demonstration of IDH1 or IDH2 mutation and 1p/19q codeletion in the tumor to diagnose oligodendroglioma or anaplastic oligodendroglioma, IDH-mutant and 1p/19q-codeleted. IDH1 R132H, ATRX and p53 immunohistochemistry may… read more here.
Keywords: immunohistochemistry; gliomas; idh mutant; h3k27me3 ... See more keywords
Imaging correlates for the 2016 update on WHO classification of grade II/III gliomas: implications for IDH, 1p/19q and ATRX status
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-017-2613-7
Abstract: The 2016 World Health Organization Classification of Tumors of the Central Nervous System incorporates the use of molecular information into the classification of brain tumors, including grade II and III gliomas, providing new prognostic information… read more here.
Keywords: classification; 19q atrx; idh mutant; grade iii ... See more keywords
Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.02.033
Abstract: Summary Cholangiocarcinoma (CCA) is an aggressive malignancy of the bile ducts, with poor prognosis and limited treatment options. Here, we describe the integrated analysis of somatic mutations, RNA expression, copy number, and DNA methylation by… read more here.
Keywords: integrative genomic; idh mutant; cholangiocarcinoma; expression ... See more keywords
Focal disruption of DNA methylation dynamics at enhancers in IDH-mutant AML cells
Sign Up to like & getrecommendations! Published in 2021 at "Leukemia"
DOI: 10.1038/s41375-021-01476-y
Abstract: Recurrent mutations in IDH1 or IDH2 in acute myeloid leukemia (AML) are associated with increased DNA methylation, but the genome-wide patterns of this hypermethylation phenotype have not been comprehensively studied in AML samples. We analyzed… read more here.
Keywords: methylation; aml; dna methylation; idh mutant ... See more keywords
Methylation and transcription patterns are distinct in IDH mutant gliomas compared to other IDH mutant cancers
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-45346-1
Abstract: Mutations in isocitrate dehydrogenases 1 and 2 (IDHmut) are present in a variety of cancers, including glioma, acute myeloid leukemia (AML), melanoma, and cholangiocarcinoma. These mutations promote hypermethylation, yet it is only a favorable prognostic… read more here.
Keywords: gliomas; gliomas compared; idh mutant; transcription patterns ... See more keywords
Spontaneous Shrinkage of isocitrate dehydrogenase (IDH)-mutant astrocytoma caused by intra-tumoural cyst rupture: a case report.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of neurosurgery"
DOI: 10.1080/02688697.2023.2170328
Abstract: BACKGROUND T2-fluid-attenuated inversion recovery (FLAIR) mismatch sign is a specific imaging finding of isocitrate dehydrogenase (IDH)-mutant astrocytomas. Histologically, a hypointense area on FLAIR images indicates the presence of microcysts. Here we report a case of… read more here.
Keywords: idh mutant; mutant astrocytoma; cyst; astrocytoma ... See more keywords
Ivosidenib in IDH-mutant cholangiocarcinoma: where do we stand?
Sign Up to like & getrecommendations! Published in 2021 at "Expert Review of Precision Medicine and Drug Development"
DOI: 10.1080/23808993.2021.1915126
Abstract: ABSTRACT Introduction: Cholangiocarcinomas (CCAs) are rare and heterogeneous malignancies associated with poor prognosis, with most of the patients presenting with advanced disease at diagnosis. The recent advent of molecular profiling has led to the identification… read more here.
Keywords: idh mutant; mutant cholangiocarcinoma; idh; ivosidenib idh ... See more keywords
Molecular classification of IDH-mutant glioblastomas based on gene expression profiles
Sign Up to like & getrecommendations! Published in 2019 at "Carcinogenesis"
DOI: 10.1093/carcin/bgz032
Abstract: Abstract Isocitrate dehydrogenase (IDH) mutant glioblastoma (GBM), accounts for ~10% GBMs, arises from lower grade diffuse glioma and preferentially appears in younger patients. Here, we aim to establish a robust gene expression-based molecular classification of… read more here.
Keywords: molecular classification; ontology; idh mutant; gene expression ... See more keywords
Cytogenetic and Molecular Characterization of IDH-Wildtype Glioblastomas and Grade 4 IDH-Mutant Astrocytomas with Unusual Histology.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlac091
Abstract: Glioblastoma (GBM) is a highly heterogenous tumor. Though several well-defined histological patterns of GBMs are known, these are infrequent, and the molecular correlates of several of these histological patterns are not well understood. We identified… read more here.
Keywords: idh mutant; idh wildtype; idh; unusual histology ... See more keywords
'Real world' use of a highly reliable imaging sign: 'T2-FLAIR mismatch' for identification of IDH mutant astrocytomas.
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-oncology"
DOI: 10.1093/neuonc/noaa041
Abstract: The T2-FLAIR mismatch sign is an easily detectable imaging sign on routine clinical MRI studies that suggests diagnosis of IDH-mutant 1p/19q non-codeleted gliomas. Multiple independent studies show that the T2-FLAIR mismatch sign has near-perfect specificity,… read more here.
Keywords: flair mismatch; idh mutant; sign; imaging sign ... See more keywords