Intraoperative detection of IDH‐mutant glioma using fluorescence lifetime imaging
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biophotonics"
DOI: 10.1002/jbio.202200291
Abstract: Identifying isocitrate dehydrogenase (IDH)‐mutation and glioma subtype during surgery instead of days later can aid in modifying tumor resection strategies for better survival outcomes. We report intraoperative identification of IDH‐mutant glioma (N = 12 patients)… read more here.
Keywords: idh mutant; mutant glioma; glioma; fluorescence lifetime ... See more keywords
Loss of H3K27 trimethylation by immunohistochemistry is frequent in oligodendroglioma, IDH-mutant and 1p/19q-codeleted, but is neither a sensitive nor a specific marker
Sign Up to like & getrecommendations! Published in 2020 at "Acta Neuropathologica"
DOI: 10.1007/s00401-019-02123-8
Abstract: The integrated diagnosis for infiltrating gliomas requires demonstration of IDH1 or IDH2 mutation and 1p/19q codeletion in the tumor to diagnose oligodendroglioma or anaplastic oligodendroglioma, IDH-mutant and 1p/19q-codeleted. IDH1 R132H, ATRX and p53 immunohistochemistry may… read more here.
Keywords: immunohistochemistry; gliomas; idh mutant; h3k27me3 ... See more keywords
Imaging correlates for the 2016 update on WHO classification of grade II/III gliomas: implications for IDH, 1p/19q and ATRX status
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-017-2613-7
Abstract: The 2016 World Health Organization Classification of Tumors of the Central Nervous System incorporates the use of molecular information into the classification of brain tumors, including grade II and III gliomas, providing new prognostic information… read more here.
Keywords: classification; 19q atrx; idh mutant; grade iii ... See more keywords
A multi-center, clinical analysis of IDH-mutant gliomas, WHO Grade 4: implications for prognosis and clinical trial design
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-024-04852-7
Abstract: Mutations in the Isocitrate Dehydrogenase (IDH) genes, IDH1 or IDH2, define a group of adult diffuse gliomas associated with a younger age at diagnosis and better prognosis than IDH wild-type glioblastoma. Within IDH mutant gliomas,… read more here.
Keywords: idh mutant; deletion; gliomas; cdkn2a deletion ... See more keywords
Do the benefits of IDH mutations in high-grade glioma persist beyond the first recurrence? A multi-institutional retrospective analysis
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-025-05049-2
Abstract: Recurrence is inevitable in both IDH wild-type glioblastoma and IDH-mutant WHO grade 3 or 4 astrocytoma. While IDH-mutant astrocytomas are associated with longer survival and delayed first progression, less is known about disease course beyond… read more here.
Keywords: idh wild; time; wild type; first recurrence ... See more keywords
Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.02.033
Abstract: Summary Cholangiocarcinoma (CCA) is an aggressive malignancy of the bile ducts, with poor prognosis and limited treatment options. Here, we describe the integrated analysis of somatic mutations, RNA expression, copy number, and DNA methylation by… read more here.
Keywords: integrative genomic; idh mutant; cholangiocarcinoma; expression ... See more keywords
Focal disruption of DNA methylation dynamics at enhancers in IDH-mutant AML cells
Sign Up to like & getrecommendations! Published in 2021 at "Leukemia"
DOI: 10.1038/s41375-021-01476-y
Abstract: Recurrent mutations in IDH1 or IDH2 in acute myeloid leukemia (AML) are associated with increased DNA methylation, but the genome-wide patterns of this hypermethylation phenotype have not been comprehensively studied in AML samples. We analyzed… read more here.
Keywords: methylation; aml; dna methylation; idh mutant ... See more keywords
Methylation and transcription patterns are distinct in IDH mutant gliomas compared to other IDH mutant cancers
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-45346-1
Abstract: Mutations in isocitrate dehydrogenases 1 and 2 (IDHmut) are present in a variety of cancers, including glioma, acute myeloid leukemia (AML), melanoma, and cholangiocarcinoma. These mutations promote hypermethylation, yet it is only a favorable prognostic… read more here.
Keywords: gliomas; gliomas compared; idh mutant; transcription patterns ... See more keywords
GlioPredictor: a deep learning model for identification of high-risk adult IDH-mutant glioma towards adjuvant treatment planning
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-51765-6
Abstract: Identification of isocitrate dehydrogenase (IDH)-mutant glioma patients at high risk of early progression is critical for radiotherapy treatment planning. Currently tools to stratify risk of early progression are lacking. We sought to identify a combination… read more here.
Keywords: progression; gliopredictor; risk; high risk ... See more keywords
Spontaneous Shrinkage of isocitrate dehydrogenase (IDH)-mutant astrocytoma caused by intra-tumoural cyst rupture: a case report.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of neurosurgery"
DOI: 10.1080/02688697.2023.2170328
Abstract: BACKGROUND T2-fluid-attenuated inversion recovery (FLAIR) mismatch sign is a specific imaging finding of isocitrate dehydrogenase (IDH)-mutant astrocytomas. Histologically, a hypointense area on FLAIR images indicates the presence of microcysts. Here we report a case of… read more here.
Keywords: idh mutant; mutant astrocytoma; cyst; astrocytoma ... See more keywords
Advances in IDH-mutant glioma management: IDH inhibitors, clinical implications of INDIGO trial, and future perspectives.
Sign Up to like & getrecommendations! Published in 2025 at "Future oncology"
DOI: 10.1080/14796694.2025.2511587
Abstract: The discovery of isocitrate dehydrogenase (IDH) mutation in gliomas marked the new era of molecular classification of CNS tumors. Understanding the complex role of IDH mutation in oncogenesis led to the evaluation of novel small… read more here.
Keywords: idh mutant; idh; indigo trial; management idh ... See more keywords