Diagnostic accuracy and potential covariates for machine learning to identify IDH mutations in glioma patients: evidence from a meta-analysis
Sign Up to like & getrecommendations! Published in 2020 at "European Radiology"
DOI: 10.1007/s00330-020-06717-9
Abstract: Objectives To assess the diagnostic accuracy of machine learning (ML) in predicting isocitrate dehydrogenase (IDH) mutations in patients with glioma and to identify potential covariates that could influence the diagnostic performance of ML. Methods A… read more here.
Keywords: machine; idh mutation; machine learning; sensitivity specificity ... See more keywords
Radiogenomic association between the T2-FLAIR mismatch sign and IDH mutation status in adult patients with lower-grade gliomas: an updated systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2022 at "European Radiology"
DOI: 10.1007/s00330-022-08607-8
Abstract: To reveal a radiogenomic correlation between the presence of the T2-fluid-attenuated inversion recovery resection (T2-FLAIR) mismatch sign on MR images and isocitrate dehydrogenase (IDH) mutation status in adult patients with lower-grade gliomas (LGGs). A web-based… read more here.
Keywords: mismatch sign; sign; flair mismatch; idh mutation ... See more keywords
Prediction of IDH Mutation Status in High-grade Gliomas Using DWI and High T1-weight DSC-MRI.
Sign Up to like & getrecommendations! Published in 2021 at "Academic radiology"
DOI: 10.1016/j.acra.2021.02.002
Abstract: RATIONALE AND OBJECTIVES We aimed to evaluate the diagnostic performance of diffusion-weighted imaging (DWI) and dynamic susceptibility contrast-enhanced (DSC) magnetic resonance imaging (MRI) parameters in the noninvasive prediction of the isocitrate dehydrogenase (IDH) mutation status… read more here.
Keywords: mutation status; idh mutation; mri; idh ... See more keywords
IDH Mutation, Competitive Inhibition of FTO, and RNA Methylation.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer cell"
DOI: 10.1016/j.ccell.2017.04.001
Abstract: A recent report published in Cancer Cell used elaborate in vitro and in vivo systems to link FTO expression to the pathogenesis of acute myeloid leukemia (AML) (Li et al., 2017). The N6-methyladenosine (m6A) RNA… read more here.
Keywords: competitive inhibition; inhibition fto; rna; fto rna ... See more keywords
Magnetic resonance imaging criteria for prediction of isocitrate dehydrogenase (IDH) mutation status in patients with grade II-III astrocytoma and oligodendroglioma
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Neurology and Neurosurgery"
DOI: 10.1016/j.clineuro.2021.106745
Abstract: BACKGROUND IDH mutation status is an important prognostic marker for glial tumors, which is detected immunohistochemically after surgery. Since this method is invasive, easy and noninvasive magnetic resonance imaging (MRI) methods have recently been used… read more here.
Keywords: mutation status; grade iii; iii astrocytoma; idh mutation ... See more keywords
Perfusion parameters derived from MRI for preoperative prediction of IDH mutation and MGMT promoter methylation status in glioblastomas.
Sign Up to like & getrecommendations! Published in 2021 at "Magnetic resonance imaging"
DOI: 10.1016/j.mri.2021.09.005
Abstract: PURPOSE To investigate the feasibility for preoperative prediction of IDH mutation and MGMT promoter methylation status in glioblastomas(GBMs) by intravoxel incoherent motion(IVIM) and dynamic susceptibility contrast(DSC). METHODS Preoperative IVIM and DSC images of 71 patients(IDH… read more here.
Keywords: idh mutation; mgmt promoter; promoter methylation; mutation ... See more keywords
IDH mutation in glioma: molecular mechanisms and potential therapeutic targets
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Cancer"
DOI: 10.1038/s41416-020-0814-x
Abstract: Isocitrate dehydrogenase (IDH) enzymes catalyse the oxidative decarboxylation of isocitrate and therefore play key roles in the Krebs cycle and cellular homoeostasis. Major advances in cancer genetics over the past decade have revealed that the… read more here.
Keywords: mutation; glioma molecular; molecular mechanisms; idh mutation ... See more keywords
Texture analysis- and support vector machine-assisted diffusional kurtosis imaging may allow in vivo gliomas grading and IDH-mutation status prediction: a preliminary study
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-24438-4
Abstract: We sought to investigate, whether texture analysis of diffusional kurtosis imaging (DKI) enhanced by support vector machine (SVM) analysis may provide biomarkers for gliomas staging and detection of the IDH mutation. First-order statistics and texture… read more here.
Keywords: analysis; texture analysis; diffusional kurtosis; idh mutation ... See more keywords
Metabolic Profiling of IDH Mutation and Malignant Progression in Infiltrating Glioma
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep44792
Abstract: Infiltrating low grade gliomas (LGGs) are heterogeneous in their behavior and the strategies used for clinical management are highly variable. A key factor in clinical decision-making is that patients with mutations in the isocitrate dehydrogenase… read more here.
Keywords: metabolic profiling; progression; mutation malignant; malignant progression ... See more keywords
IDH mutation and cancer stem cell.
Sign Up to like & getrecommendations! Published in 2022 at "Essays in biochemistry"
DOI: 10.1042/ebc20220008
Abstract: Cancer stem cells (CSCs) are a small population of cells in human malignancies that resemble the biology of human pluripotent stem cells. CSCs are closely related to the critical hallmarks in human cancers, ranging from… read more here.
Keywords: idh mutation; stem; human cancers; cancer stem ... See more keywords
The clinical use of IDH1 and IDH2 mutations in gliomas
Sign Up to like & getrecommendations! Published in 2018 at "Expert Review of Molecular Diagnostics"
DOI: 10.1080/14737159.2018.1548935
Abstract: ABSTRACT Introduction: Mutations in the genes isocitrate dehydrogenase (IDH) 1 and 2 have been reported in a limited number of tumors. In gliomas, IDH mutations are primarily detected in WHO grade II–III tumors and represent… read more here.
Keywords: use; idh mutations; idh; role ... See more keywords