LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "idh mutation" as a keyword



Enhancing predictability of IDH mutation status in glioma patients at initial diagnosis: a comparative analysis of radiomics from MRI, [18F]FET PET, and TSPO PET

Sign Up to like & get
recommendations! Published in 2024 at "European Journal of Nuclear Medicine and Molecular Imaging"

DOI: 10.1007/s00259-024-06654-5

Abstract: According to the World Health Organization classification for tumors of the central nervous system, mutation status of the isocitrate dehydrogenase (IDH) genes has become a major diagnostic discriminator for gliomas. Therefore, imaging-based prediction of IDH… read more here.

Keywords: mutation status; 18f fet; idh mutation; fet pet ... See more keywords
Photo from wikipedia

Diagnostic accuracy and potential covariates for machine learning to identify IDH mutations in glioma patients: evidence from a meta-analysis

Sign Up to like & get
recommendations! Published in 2020 at "European Radiology"

DOI: 10.1007/s00330-020-06717-9

Abstract: Objectives To assess the diagnostic accuracy of machine learning (ML) in predicting isocitrate dehydrogenase (IDH) mutations in patients with glioma and to identify potential covariates that could influence the diagnostic performance of ML. Methods A… read more here.

Keywords: machine; idh mutation; machine learning; sensitivity specificity ... See more keywords

Radiogenomic association between the T2-FLAIR mismatch sign and IDH mutation status in adult patients with lower-grade gliomas: an updated systematic review and meta-analysis

Sign Up to like & get
recommendations! Published in 2022 at "European Radiology"

DOI: 10.1007/s00330-022-08607-8

Abstract: To reveal a radiogenomic correlation between the presence of the T2-fluid-attenuated inversion recovery resection (T2-FLAIR) mismatch sign on MR images and isocitrate dehydrogenase (IDH) mutation status in adult patients with lower-grade gliomas (LGGs). A web-based… read more here.

Keywords: mismatch sign; sign; flair mismatch; idh mutation ... See more keywords

Deep learning-based quantification of T2-FLAIR mismatch sign: extending IDH mutation prediction in adult-type diffuse lower-grade glioma

Sign Up to like & get
recommendations! Published in 2025 at "European Radiology"

DOI: 10.1007/s00330-025-11475-7

Abstract: To investigate the predictive value of the quantitative T2-FLAIR mismatch ratio (qT2FM) with fully automated tumor segmentation in adult-type diffuse lower-grade gliomas (LGGs). This retrospective study included 218 consecutive patients (mean age, 47 years ± 15 [SD];… read more here.

Keywords: adult type; flair mismatch; idh mutation; mutation ... See more keywords

Prediction of IDH Mutation Status in High-grade Gliomas Using DWI and High T1-weight DSC-MRI.

Sign Up to like & get
recommendations! Published in 2021 at "Academic radiology"

DOI: 10.1016/j.acra.2021.02.002

Abstract: RATIONALE AND OBJECTIVES We aimed to evaluate the diagnostic performance of diffusion-weighted imaging (DWI) and dynamic susceptibility contrast-enhanced (DSC) magnetic resonance imaging (MRI) parameters in the noninvasive prediction of the isocitrate dehydrogenase (IDH) mutation status… read more here.

Keywords: mutation status; idh mutation; mri; idh ... See more keywords
Photo by nci from unsplash

IDH Mutation, Competitive Inhibition of FTO, and RNA Methylation.

Sign Up to like & get
recommendations! Published in 2017 at "Cancer cell"

DOI: 10.1016/j.ccell.2017.04.001

Abstract: A recent report published in Cancer Cell used elaborate in vitro and in vivo systems to link FTO expression to the pathogenesis of acute myeloid leukemia (AML) (Li et al., 2017). The N6-methyladenosine (m6A) RNA… read more here.

Keywords: competitive inhibition; inhibition fto; rna; fto rna ... See more keywords
Photo from wikipedia

Magnetic resonance imaging criteria for prediction of isocitrate dehydrogenase (IDH) mutation status in patients with grade II-III astrocytoma and oligodendroglioma

Sign Up to like & get
recommendations! Published in 2021 at "Clinical Neurology and Neurosurgery"

DOI: 10.1016/j.clineuro.2021.106745

Abstract: BACKGROUND IDH mutation status is an important prognostic marker for glial tumors, which is detected immunohistochemically after surgery. Since this method is invasive, easy and noninvasive magnetic resonance imaging (MRI) methods have recently been used… read more here.

Keywords: mutation status; grade iii; iii astrocytoma; idh mutation ... See more keywords
Photo from wikipedia

Perfusion parameters derived from MRI for preoperative prediction of IDH mutation and MGMT promoter methylation status in glioblastomas.

Sign Up to like & get
recommendations! Published in 2021 at "Magnetic resonance imaging"

DOI: 10.1016/j.mri.2021.09.005

Abstract: PURPOSE To investigate the feasibility for preoperative prediction of IDH mutation and MGMT promoter methylation status in glioblastomas(GBMs) by intravoxel incoherent motion(IVIM) and dynamic susceptibility contrast(DSC). METHODS Preoperative IVIM and DSC images of 71 patients(IDH… read more here.

Keywords: idh mutation; mgmt promoter; promoter methylation; mutation ... See more keywords
Photo by nci from unsplash

IDH mutation in glioma: molecular mechanisms and potential therapeutic targets

Sign Up to like & get
recommendations! Published in 2020 at "British Journal of Cancer"

DOI: 10.1038/s41416-020-0814-x

Abstract: Isocitrate dehydrogenase (IDH) enzymes catalyse the oxidative decarboxylation of isocitrate and therefore play key roles in the Krebs cycle and cellular homoeostasis. Major advances in cancer genetics over the past decade have revealed that the… read more here.

Keywords: mutation; glioma molecular; molecular mechanisms; idh mutation ... See more keywords

Texture analysis- and support vector machine-assisted diffusional kurtosis imaging may allow in vivo gliomas grading and IDH-mutation status prediction: a preliminary study

Sign Up to like & get
recommendations! Published in 2018 at "Scientific Reports"

DOI: 10.1038/s41598-018-24438-4

Abstract: We sought to investigate, whether texture analysis of diffusional kurtosis imaging (DKI) enhanced by support vector machine (SVM) analysis may provide biomarkers for gliomas staging and detection of the IDH mutation. First-order statistics and texture… read more here.

Keywords: analysis; texture analysis; diffusional kurtosis; idh mutation ... See more keywords

Metabolic Profiling of IDH Mutation and Malignant Progression in Infiltrating Glioma

Sign Up to like & get
recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/srep44792

Abstract: Infiltrating low grade gliomas (LGGs) are heterogeneous in their behavior and the strategies used for clinical management are highly variable. A key factor in clinical decision-making is that patients with mutations in the isocitrate dehydrogenase… read more here.

Keywords: metabolic profiling; progression; mutation malignant; malignant progression ... See more keywords