Chemoradiotherapy with temozolomide vs. radiotherapy alone in patients with IDH wild‐type and TERT promoter mutation histological grade 2/3 gliomas: An extension retrospective analysis of a randomized controlled trial
Sign Up to like & getrecommendations! Published in 2025 at "Cancer"
DOI: 10.1002/cncr.70171
Abstract: Given the poor prognosis of IDH wild‐type (IDH‐wt) and telomerase reverse transcriptase promoter mutation (TERTp‐mut) histological grade 2 to 3 gliomas, the World Health Organization has reclassified it as molecular glioblastoma. However, the effectiveness of… read more here.
Keywords: idh wild; radiotherapy alone; histological grade; wild type ... See more keywords
Do the benefits of IDH mutations in high-grade glioma persist beyond the first recurrence? A multi-institutional retrospective analysis
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-025-05049-2
Abstract: Recurrence is inevitable in both IDH wild-type glioblastoma and IDH-mutant WHO grade 3 or 4 astrocytoma. While IDH-mutant astrocytomas are associated with longer survival and delayed first progression, less is known about disease course beyond… read more here.
Keywords: idh wild; time; wild type; first recurrence ... See more keywords
Relationship between molecular characteristics of glioblastoma multiforme and the subventricular zone.
Sign Up to like & getrecommendations! Published in 2022 at "British journal of neurosurgery"
DOI: 10.1080/02688697.2021.2024144
Abstract: OBJECTIVE This study aims to assess the relationship between the molecular characteristics of glioblastoma multiforme (GBM) and the subventricular zone (SVZ). MATERIAL AND METHODS Eligible patients had their data anonymously collected from an institutional database,… read more here.
Keywords: type; tumour; molecular characteristics; gbms ... See more keywords
PATH-05. A RETROSPECTIVE STUDY OF TREATMENT STRATEGIES AND OUTCOMES IN WHO GRADE II AND III ISOCITRATE DEHYDROGENASE (IDH) WILD-TYPE ASTROCYTOMA
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-oncology"
DOI: 10.1093/neuonc/noaa215.687
Abstract: WHO grade II and III IDH wild-type astrocytomas behave more aggressively than their IDH mutated counterparts. A subpopulation shares molecular features with the novel entity proposed in cIMPACT-NOW Update 3 “Diffuse astrocytic glioma, IDH wild-type,… read more here.
Keywords: grade iii; idh wild; wild type;
DISP-17. OUTCOMES, CLINICAL AND MOLECULAR CHARACTERISTICS OF HISPANIC PATIENTS WITH IDH WILDTYPE GLIOBLASTOMA
Sign Up to like & getrecommendations! Published in 2024 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noae165.0590
Abstract: Knowledge about outcomes in Hispanic patients with gliomas is scant and mainly derived from tumor registries. IDH wild-type glioblastomas (GBM) are the most common and aggressive malignant primary brain tumor. Hispanics account for 19% of… read more here.
Keywords: hispanic patients; idh wild; molecular characteristics; clinical molecular ... See more keywords
IMG-15. A Synergistic AI Framework using Graph and Texture for Non-Invasive Survival Prediction in IDH-Wild-Type Glioblastoma Multiforme
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaf201.1094
Abstract: Glioblastoma multiforme (GBM), specifically the IDH-wild-type subtype, is an aggressive brain tumor with a median survival of 12–18 months. Non-invasive estimation of overall survival (OS) is very much crucial for personalized treatment strategies. However, existing… read more here.
Keywords: oncology; texture; idh wild; wild type ... See more keywords
Does Limited-Margin Radiotherapy Change the Recurrence Pattern and Survival of Patients With IDH-Wild-Type Glioblastoma? Analysis and Validation of a Different Approach.
Sign Up to like & getrecommendations! Published in 2025 at "Asia-Pacific journal of clinical oncology"
DOI: 10.1111/ajco.70014
Abstract: PURPOSE We aimed to analyze our radiotherapy protocol by evaluating its effect on recurrence patterns and survival outcomes. METHODS We assessed 69 patients diagnosed with IDH-wild-type glioblastoma who underwent chemoradiotherapy at our institution from January… read more here.
Keywords: type glioblastoma; idh wild; radiotherapy; wild type ... See more keywords
Molecular landscape of IDH‐wild‐type, H3‐wild‐type glioblastomas of adolescents and young adults
Sign Up to like & getrecommendations! Published in 2022 at "Neuropathology and Applied Neurobiology"
DOI: 10.1111/nan.12802
Abstract: We aimed to characterise glioblastomas of adolescents and young adults (AYAs) that were isocitrate dehydrogenase (IDH) wild type (wt) and H3wt. read more here.
Keywords: adolescents young; young adults; type; idh wild ... See more keywords
MGMT methylation as a prognostic factor in IDH wild type anaplastic gliomas.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.2523
Abstract: 2523Background: Anaplastic gliomas are classified according to the presence of IDH-mutation. IDH wild type (IDH wt) is associated with poor prognosis and limited effectiveness of treatments.The aim... read more here.
Keywords: idh wild; anaplastic gliomas; wild type; idh ... See more keywords
The efficacy of an unrestricted cycling ketogenic diet in preclinical models of IDH wild-type and IDH mutant glioma
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0257725
Abstract: Infiltrative gliomas are the most common neoplasms arising in the brain, and remain largely incurable despite decades of research. A subset of these gliomas contains mutations in isocitrate dehydrogenase 1 (IDH1mut) or, less commonly, IDH2… read more here.
Keywords: unrestricted cycling; gliomas; glioma; idh wild ... See more keywords
Prolonged response of recurrent IDH-wild-type glioblastoma to laser interstitial thermal therapy with pembrolizumab
Sign Up to like & getrecommendations! Published in 2022 at "CNS Oncology"
DOI: 10.2217/cns-2021-0013
Abstract: Despite the improved understanding of the molecular and genetic heterogeneity of glioblastoma, there is still an unmet need for better therapeutics, as treatment approaches have remained unchanged in recent years. Research into the role of… read more here.
Keywords: glioblastoma; laser interstitial; interstitial thermal; thermal therapy ... See more keywords