Relationship between molecular characteristics of glioblastoma multiforme and the subventricular zone.
Sign Up to like & getrecommendations! Published in 2022 at "British journal of neurosurgery"
DOI: 10.1080/02688697.2021.2024144
Abstract: OBJECTIVE This study aims to assess the relationship between the molecular characteristics of glioblastoma multiforme (GBM) and the subventricular zone (SVZ). MATERIAL AND METHODS Eligible patients had their data anonymously collected from an institutional database,… read more here.
Keywords: type; tumour; molecular characteristics; gbms ... See more keywords
PATH-05. A RETROSPECTIVE STUDY OF TREATMENT STRATEGIES AND OUTCOMES IN WHO GRADE II AND III ISOCITRATE DEHYDROGENASE (IDH) WILD-TYPE ASTROCYTOMA
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-oncology"
DOI: 10.1093/neuonc/noaa215.687
Abstract: WHO grade II and III IDH wild-type astrocytomas behave more aggressively than their IDH mutated counterparts. A subpopulation shares molecular features with the novel entity proposed in cIMPACT-NOW Update 3 “Diffuse astrocytic glioma, IDH wild-type,… read more here.
Keywords: grade iii; idh wild; wild type;
Molecular landscape of IDH‐wild‐type, H3‐wild‐type glioblastomas of adolescents and young adults
Sign Up to like & getrecommendations! Published in 2022 at "Neuropathology and Applied Neurobiology"
DOI: 10.1111/nan.12802
Abstract: We aimed to characterise glioblastomas of adolescents and young adults (AYAs) that were isocitrate dehydrogenase (IDH) wild type (wt) and H3wt. read more here.
Keywords: adolescents young; young adults; type; idh wild ... See more keywords
MGMT methylation as a prognostic factor in IDH wild type anaplastic gliomas.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.2523
Abstract: 2523Background: Anaplastic gliomas are classified according to the presence of IDH-mutation. IDH wild type (IDH wt) is associated with poor prognosis and limited effectiveness of treatments.The aim... read more here.
Keywords: idh wild; anaplastic gliomas; wild type; idh ... See more keywords
The efficacy of an unrestricted cycling ketogenic diet in preclinical models of IDH wild-type and IDH mutant glioma
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DOI: 10.1371/journal.pone.0257725
Abstract: Infiltrative gliomas are the most common neoplasms arising in the brain, and remain largely incurable despite decades of research. A subset of these gliomas contains mutations in isocitrate dehydrogenase 1 (IDH1mut) or, less commonly, IDH2… read more here.
Keywords: unrestricted cycling; gliomas; glioma; idh wild ... See more keywords
Prolonged response of recurrent IDH-wild-type glioblastoma to laser interstitial thermal therapy with pembrolizumab
Sign Up to like & getrecommendations! Published in 2022 at "CNS Oncology"
DOI: 10.2217/cns-2021-0013
Abstract: Despite the improved understanding of the molecular and genetic heterogeneity of glioblastoma, there is still an unmet need for better therapeutics, as treatment approaches have remained unchanged in recent years. Research into the role of… read more here.
Keywords: glioblastoma; laser interstitial; interstitial thermal; thermal therapy ... See more keywords
Ultra-Mutation in IDH Wild-Type Glioblastomas of Patients Younger than 55 Years is Associated with Defective Mismatch Repair, Microsatellite Instability, and Giant Cell Enrichment
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DOI: 10.3390/cancers11091279
Abstract: Background: Glioblastomas (GBMs) are classified into isocitrate dehydrogenase (IDH) mutants and IDH wild-types (IDH-wt). This study aimed at identifying the mutational assets of IDH-wt GBMs in patients aged 18–54 years for which limited data are… read more here.
Keywords: glioblastomas; idh wild; idh gbms; microsatellite instability ... See more keywords
MRI-Based Radiomics Combined with Deep Learning for Distinguishing IDH-Mutant WHO Grade 4 Astrocytomas from IDH-Wild-Type Glioblastomas
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DOI: 10.3390/cancers15030951
Abstract: Simple Summary To differentiate IDH-mutant grade 4 astrocytomas from IDH-wild-type glioblastomas, two MRI sequences (post-contrast T1 and T2-FLAIR) were acquired from 57 patients. The images were resliced, resampled, and realigned. In the next step, tumors… read more here.
Keywords: idh mutant; mutant grade; astrocytomas idh; idh ... See more keywords
The Role of EGFR Amplification in Deep Venous Thrombosis Occurrence in IDH Wild-Type Glioblastoma
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DOI: 10.3390/curroncol30050373
Abstract: Introduction: Glioblastoma (GBM) patients have a 20–30 incidence of venous thromboembolic events. EGFR is a widely used prognostic marker for many cancers. Recent lung cancer studies have described relationships between EGFR amplification and an increased… read more here.
Keywords: glioblastoma; egfr amplification; status; amplification ... See more keywords