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   Articles with "idh wildtype" as a keyword



Distribution and favorable prognostic implication of genomic EGFR alterations in IDH ‐wildtype glioblastoma

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recommendations! Published in 2022 at "Cancer Medicine"

DOI: 10.1002/cam4.4939

Abstract: We aimed to evaluate the mutation profile, transcriptional variants, and prognostic impact of the epidermal growth factor receptor (EGFR) gene in isocitrate dehydrogenase (IDH)‐wildtype glioblastomas (GBMs). read more here.

Keywords: distribution favorable; idh wildtype; favorable prognostic; prognostic implication ... See more keywords

Shape matters: unsupervised exploration of IDH-wildtype glioma imaging survival predictors

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recommendations! Published in 2024 at "European Radiology"

DOI: 10.1007/s00330-024-11042-6

Abstract: This study examines clustering based on shape radiomic features and tumor volume to identify IDH-wildtype glioma phenotypes and assess their impact on overall survival (OS). This retrospective study included 436 consecutive patients diagnosed with IDH-wt… read more here.

Keywords: tumor volume; idh wildtype; volume; glioma ... See more keywords

Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations

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recommendations! Published in 2018 at "Acta Neuropathologica"

DOI: 10.1007/s00401-018-1837-8

Abstract: Tumors with histological features of pilocytic astrocytoma (PA), but with increased mitotic activity and additional high-grade features (particularly microvascular proliferation and palisading necrosis) have often been designated anaplastic pilocytic astrocytomas. The status of these tumors… read more here.

Keywords: astrocytoma piloid; mapk pathway; anaplastic astrocytoma; idh wildtype ... See more keywords

Diagnostic implications of TERT promoter mutation status in diffuse gliomas in a routine clinical setting

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recommendations! Published in 2017 at "Virchows Archiv"

DOI: 10.1007/s00428-017-2216-x

Abstract: IDH (isocitrate dehydrogenase) gene mutations are present in most diffuse low-grade gliomas and define the clinico-pathological core of the respective morphologically defined entities. Conversely, according to the 2016 WHO classification, the majority of glioblastomas belong… read more here.

Keywords: promoter mutation; tert promoter; diffuse gliomas; idh wildtype ... See more keywords

Socioeconomic influences on survival outcome in idh-wildtype glioma patients: examining the role of age, education, and lifestyle factors

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recommendations! Published in 2025 at "Acta Neurochirurgica"

DOI: 10.1007/s00701-025-06594-5

Abstract: Socioeconomic factors influence survival in different cancer types. This study aimed to assess the impact of various socioeconomic factors, including education, marital status, lifestyle, and social network, on survival in patients with Isocitrate dehydrogenase (IDH)… read more here.

Keywords: education; idh wildtype; glioma patients; wildtype glioma ... See more keywords

How I do it: > 8 Carmustine wafer implantation during supra-marginal resection of a glioblastoma, IDH-wildtype

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recommendations! Published in 2025 at "Acta Neurochirurgica"

DOI: 10.1007/s00701-025-06675-5

Abstract: The maximal safe resection of glioblastoma, IDH-wildtype often creates a large resection cavity that can accommodate more than eight Carmustine implants. We detail the implantation technique of 13 Carmustine wafers within the surgical bed after… read more here.

Keywords: idh wildtype; resection; resection glioblastoma; carmustine ... See more keywords

Diffuse astrocytic glioma, IDH-Wildtype, with molecular features of glioblastoma, WHO grade IV: A single-institution case series and review

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recommendations! Published in 2021 at "Journal of Neuro-Oncology"

DOI: 10.1007/s11060-020-03677-4

Abstract: Objective In 2018, cIMPACT-NOW update 3 concluded that WHO grade II/III IDH-wildtype diffuse astrocytomas that contain TERT promoter mutations, chromosome 7 gain/10 loss, and/or EGFR amplification, correspond to a WHO grade IV diagnosis and should… read more here.

Keywords: diffuse astrocytic; institution; idh; idh wildtype ... See more keywords

Tumor and immune cell distribution in the tumor core and outer part of glioblastoma, IDH wildtype

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recommendations! Published in 2025 at "Journal of Neuro-Oncology"

DOI: 10.1007/s11060-025-05232-5

Abstract: Glioblastoma, IDH-wildtype is the most frequent and malignant primary brain tumor in adults. Tumor cells infiltrate the brain parenchyma, preventing complete resection and causing progression. Immune therapies have limited effect, but little is known about… read more here.

Keywords: core; idh wildtype; tumor; cell ... See more keywords

Extensive Leptomeningeal Intracranial and Spinal Metastases in a Patient with a Supratentorial Glioblastoma Multiforme, IDH-Wildtype.

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recommendations! Published in 2018 at "World neurosurgery"

DOI: 10.1016/j.wneu.2018.09.082

Abstract: BACKGROUND Glioblastoma multiforme (GBM) is usually characterized by diffuse, infiltrative growth and local tumor progression. Extensive leptomeningeal metastases are rarely observed. It is unclear which GBMs are prone to this specific growth pattern and progression,… read more here.

Keywords: idh wildtype; glioblastoma multiforme; extensive leptomeningeal; tumor ... See more keywords

Cytogenetic and Molecular Characterization of IDH-Wildtype Glioblastomas and Grade 4 IDH-Mutant Astrocytomas with Unusual Histology.

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recommendations! Published in 2022 at "Journal of neuropathology and experimental neurology"

DOI: 10.1093/jnen/nlac091

Abstract: Glioblastoma (GBM) is a highly heterogenous tumor. Though several well-defined histological patterns of GBMs are known, these are infrequent, and the molecular correlates of several of these histological patterns are not well understood. We identified… read more here.

Keywords: idh mutant; idh wildtype; idh; unusual histology ... See more keywords

NIMG-36. AUTOMATIC STRATIFICATION OF ENHANCING AND NON-ENHANCING GLIOMAS INTO GENETIC SUBTYPES USING DEEP NEURAL NETWORKS AND DIFFUSION-WEIGHTED IMAGING

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recommendations! Published in 2020 at "Neuro-oncology"

DOI: 10.1093/neuonc/noaa215.649

Abstract: Current WHO guidelines emphasize classification of diffuse gliomas by genetic alterations into three subgroups: 1) IDH-wildtype; 2) IDH-mutant, 1p/19q-codeleted; and 3) IDH-mutant, 1p/19q-non-codeleted. Non-invasive genetic characterization can benefit patients with inoperable lesions or who are… read more here.

Keywords: gliomas genetic; idh mutant; non enhancing; idh wildtype ... See more keywords