Distribution and favorable prognostic implication of genomic EGFR alterations in IDH ‐wildtype glioblastoma
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4939
Abstract: We aimed to evaluate the mutation profile, transcriptional variants, and prognostic impact of the epidermal growth factor receptor (EGFR) gene in isocitrate dehydrogenase (IDH)‐wildtype glioblastomas (GBMs). read more here.
Keywords: distribution favorable; idh wildtype; favorable prognostic; prognostic implication ... See more keywords
Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations
Sign Up to like & getrecommendations! Published in 2018 at "Acta Neuropathologica"
DOI: 10.1007/s00401-018-1837-8
Abstract: Tumors with histological features of pilocytic astrocytoma (PA), but with increased mitotic activity and additional high-grade features (particularly microvascular proliferation and palisading necrosis) have often been designated anaplastic pilocytic astrocytomas. The status of these tumors… read more here.
Keywords: astrocytoma piloid; mapk pathway; anaplastic astrocytoma; idh wildtype ... See more keywords
Diagnostic implications of TERT promoter mutation status in diffuse gliomas in a routine clinical setting
Sign Up to like & getrecommendations! Published in 2017 at "Virchows Archiv"
DOI: 10.1007/s00428-017-2216-x
Abstract: IDH (isocitrate dehydrogenase) gene mutations are present in most diffuse low-grade gliomas and define the clinico-pathological core of the respective morphologically defined entities. Conversely, according to the 2016 WHO classification, the majority of glioblastomas belong… read more here.
Keywords: promoter mutation; tert promoter; diffuse gliomas; idh wildtype ... See more keywords
Diffuse astrocytic glioma, IDH-Wildtype, with molecular features of glioblastoma, WHO grade IV: A single-institution case series and review
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-020-03677-4
Abstract: Objective In 2018, cIMPACT-NOW update 3 concluded that WHO grade II/III IDH-wildtype diffuse astrocytomas that contain TERT promoter mutations, chromosome 7 gain/10 loss, and/or EGFR amplification, correspond to a WHO grade IV diagnosis and should… read more here.
Keywords: diffuse astrocytic; institution; idh; idh wildtype ... See more keywords
Extensive Leptomeningeal Intracranial and Spinal Metastases in a Patient with a Supratentorial Glioblastoma Multiforme, IDH-Wildtype.
Sign Up to like & getrecommendations! Published in 2018 at "World neurosurgery"
DOI: 10.1016/j.wneu.2018.09.082
Abstract: BACKGROUND Glioblastoma multiforme (GBM) is usually characterized by diffuse, infiltrative growth and local tumor progression. Extensive leptomeningeal metastases are rarely observed. It is unclear which GBMs are prone to this specific growth pattern and progression,… read more here.
Keywords: idh wildtype; glioblastoma multiforme; extensive leptomeningeal; tumor ... See more keywords
Cytogenetic and Molecular Characterization of IDH-Wildtype Glioblastomas and Grade 4 IDH-Mutant Astrocytomas with Unusual Histology.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlac091
Abstract: Glioblastoma (GBM) is a highly heterogenous tumor. Though several well-defined histological patterns of GBMs are known, these are infrequent, and the molecular correlates of several of these histological patterns are not well understood. We identified… read more here.
Keywords: idh mutant; idh wildtype; idh; unusual histology ... See more keywords
NIMG-36. AUTOMATIC STRATIFICATION OF ENHANCING AND NON-ENHANCING GLIOMAS INTO GENETIC SUBTYPES USING DEEP NEURAL NETWORKS AND DIFFUSION-WEIGHTED IMAGING
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-oncology"
DOI: 10.1093/neuonc/noaa215.649
Abstract: Current WHO guidelines emphasize classification of diffuse gliomas by genetic alterations into three subgroups: 1) IDH-wildtype; 2) IDH-mutant, 1p/19q-codeleted; and 3) IDH-mutant, 1p/19q-non-codeleted. Non-invasive genetic characterization can benefit patients with inoperable lesions or who are… read more here.
Keywords: gliomas genetic; idh mutant; non enhancing; idh wildtype ... See more keywords
Prospective genomically guided identification of “early/evolving” and “undersampled” IDH-wildtype glioblastoma leads to improved clinical outcomes
Sign Up to like & getrecommendations! Published in 2022 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noac089
Abstract: Abstract Background Genomic profiling studies of diffuse gliomas have led to new improved classification schemes that better predict patient outcomes compared to conventional histomorphology alone. One example is the recognition that patients with IDH-wildtype diffuse… read more here.
Keywords: idh wildtype; glioblastoma; evolving undersampled; early evolving ... See more keywords
INNV-16. COMPLETE RESPONSE OF THALAMIC IDH WILDTYPE GLIOBLASTOMA AFTER PROTON THERAPY FOLLOWED BY CHEMOTHERAPY TOGETHER WITH TUMOR TREATING FIELDS
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz175.559
Abstract: Proton therapy is able to apply high radiation doses to the tumor while sparing healthy tissues by reducing integral dose. Tumor Treating Fields (TTFields) are low intensity (1–3 V/cm) and intermediate frequency (100–300 kHz) alternating… read more here.
Keywords: proton therapy; idh wildtype; wildtype; response ... See more keywords
Epigenetic profiling reveals a strong association between lack of 5-ALA fluorescence and EGFR amplification in IDH-wildtype glioblastoma
Sign Up to like & getrecommendations! Published in 2023 at "Neuro-Oncology Practice"
DOI: 10.1093/nop/npad025
Abstract: 5-aminolevulinic acid (5-ALA) fluorescence-guided resection increases the percentage of complete CNS tumor resections and improves the progression-free survival of IDH-wildtype glioblastoma patients. A small subset of IDH-wildtype glioblastoma show no 5-ALA fluorescence. An explanation for… read more here.
Keywords: idh wildtype; fluorescence; glioblastoma; ala fluorescence ... See more keywords
Elevated ratio of C-type lectin-like receptor 2 level and platelet count (C2PAC) aids in the diagnosis of post-operative venous thromboembolism in IDH-wildtype gliomas.
Sign Up to like & getrecommendations! Published in 2023 at "Thrombosis research"
DOI: 10.2139/ssrn.4226393
Abstract: INTRODUCTION Podoplanin (PDPN) is known to induce platelet aggregation via interacting with the C-type lectin-like receptor-2 on platelets and is involved in postoperative venous thromboembolism (VTE) formation. In this study, we investigate the correlation between… read more here.
Keywords: platelet; gliomas; idh wildtype; wildtype gliomas ... See more keywords