A Potent Blood–Brain Barrier-Permeable Mutant IDH1 Inhibitor Suppresses the Growth of Glioblastoma with IDH1 Mutation in a Patient-Derived Orthotopic Xenograft Model
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-18-1349
Abstract: Gliomas are the second most common primary brain tumors in adults. They are treated with combination therapies, including surgery, radiotherapy, and chemotherapy. There are currently limited treatment options for recurrent gliomas, and new targeted therapies… read more here.
Keywords: idh1 inhibitor; idh1; mutant idh1; xenograft ... See more keywords
The IDH1 Inhibitor Ivosidenib May Slow IDH1-Mutant Glioma Progression.
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DOI: 10.1158/2159-8290.cd-rw2020-095
Abstract: Ivosidenib, an inhibitor of mutant IDH1, was safe and showed early evidence of efficacy in glioma. read more here.
Keywords: ivosidenib; glioma; inhibitor ivosidenib; idh1 inhibitor ... See more keywords