Decitabine and venetoclax for IDH1/2‐mutated acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Hematology"
DOI: 10.1002/ajh.26122
Abstract: Kaushansky K, Lichtman MA, Prchal JT, Levi M, Burns LJ, Linch DC, eds. Williams Hematology. 10th ed. New York: McGraw Hill; 2020:721-748. 5. Ho PJ, Wickramasinghe SN, Rees DC, Lee MJ, Eden A, Thein SL.… read more here.
Keywords: hematology; venetoclax idh1; idh1 mutated; acute myeloid ... See more keywords
Platinum sensitivity in patients with IDH1/2 mutated vs wild‐type intrahepatic cholangiocarcinoma: A propensity score‐based study
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34182
Abstract: Isocitrate dehydrogenase (IDH)1/2 mutations are the most frequent druggable alterations in intrahepatic cholangiocarcinoma (iCCA), reported in ~20% of cases. Preclinical evidence indicates that these mutations are associated with homologous recombination deficiency (HRD), which could be… read more here.
Keywords: intrahepatic cholangiocarcinoma; idh1 mutated; idh1 mutations; platinum ... See more keywords
Targeting IDH1-Mutated Malignancies with NRF2 Blockade.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the National Cancer Institute"
DOI: 10.1093/jnci/djy230
Abstract: Background Neomorphic IDH1 mutations disrupt the redox balance by promoting reactive oxygen species (ROS) production. However, the mechanism by which IDH1-mutant cells maintain ROS homeostasis remains elusive. It is also not known whether reprogrammed ROS… read more here.
Keywords: nrf2 blockade; mutated cells; idh1 mutated; idh1 ... See more keywords
Chemosensitivity of IDH1-Mutated Gliomas Due to an Impairment in PARP1-Mediated DNA Repair.
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DOI: 10.1158/0008-5472.can-16-2773
Abstract: Mutations in isocitrate dehydrogenase (IDH) are the most prevalent genetic abnormalities in lower grade gliomas. The presence of these mutations in glioma is prognostic for better clinical outcomes with longer patient survival. In the present… read more here.
Keywords: idh1 mutated; mutated gliomas; dna repair; repair ... See more keywords
Abstract 872: IDH1-mutated cancer cells are sensitive to cisplatin and an IDH1-mutant inhibitor counteracts this sensitivity
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-872
Abstract: Isocitrate dehydrogenase 1 (IDH1) is mutated in various types of human cancer and predicts improved response to treatment with irradiation or chemotherapy. Mutated IDH1 enzymes catalyze neomorphic conversion of α-ketoglutarate (α-KG) to the oncometabolite D-2-hydroxyglutarate… read more here.
Keywords: treatment; cisplatin; idh1 mutated; idh1 ... See more keywords