Platinum sensitivity in patients with IDH1/2 mutated vs wild‐type intrahepatic cholangiocarcinoma: A propensity score‐based study
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34182
Abstract: Isocitrate dehydrogenase (IDH)1/2 mutations are the most frequent druggable alterations in intrahepatic cholangiocarcinoma (iCCA), reported in ~20% of cases. Preclinical evidence indicates that these mutations are associated with homologous recombination deficiency (HRD), which could be… read more here.
Keywords: intrahepatic cholangiocarcinoma; idh1 mutated; idh1 mutations; platinum ... See more keywords
Oncogenic Activities of IDH1/2 Mutations: From Epigenetics to Cellular Signaling.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2017.06.002
Abstract: Gliomas and leukemias remain highly refractory to treatment, thus highlighting the need for new and improved therapeutic strategies. Mutations in genes encoding enzymes involved in the tricarboxylic acid (TCA) cycle, such as the isocitrate dehydrogenases… read more here.
Keywords: activities idh1; oncogenic activities; idh1 mutations; mutations epigenetics ... See more keywords
Nucleophosmin1 and isocitrate dehydrogenase 1 and 2 as measurable residual disease markers in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2021 at "PLoS ONE"
DOI: 10.1371/journal.pone.0253386
Abstract: Monitoring measurable residual disease (MRD) in acute myeloid leukemia (AML) plays an important role in predicting relapse and outcome. The applicability of the leukemia-initiating nucleophosmin1 (NPM1) gene mutations in MRD detection is well-established, while that… read more here.
Keywords: mrd; idh1 mutations; measurable residual; residual disease ... See more keywords
Cancer-associated IDH mutations induce Glut1 expression and glucose metabolic disorders through a PI3K/Akt/mTORC1-Hif1α axis
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DOI: 10.1371/journal.pone.0257090
Abstract: Isocitrate dehydrogenase 1 and 2 (IDH1/2) mutations and their key effector 2-hydroxyglutarate (2-HG) have been reported to promote oncogenesis in various human cancers. To elucidate molecular mechanism(s) associated with IDH1/2 mutations, we established mouse embryonic… read more here.
Keywords: associated idh; idh1 mutations; pi3k akt; expression ... See more keywords
Opposed Interplay between IDH1 Mutations and the WNT/β-Catenin Pathway: Added Information for Glioma Classification
Sign Up to like & getrecommendations! Published in 2021 at "Biomedicines"
DOI: 10.3390/biomedicines9060619
Abstract: Gliomas are the main common primary intraparenchymal brain tumor in the central nervous system (CNS), with approximately 7% of the death caused by cancers. In the WHO 2016 classification, molecular dysregulations are part of the… read more here.
Keywords: classification; gliomas; idh1 mutations; catenin pathway ... See more keywords
Detection of IDH1 Mutations in Plasma Using BEAMing Technology in Patients with Gliomas
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14122891
Abstract: Simple Summary In contrast with other solid tumors, only a few, small studies have shown the feasibility of detecting different biomarkers in the peripheral blood (PB) of patients with gliomas. A prospective study was conducted,… read more here.
Keywords: idh1; mutations plasma; patients gliomas; idh1 mutations ... See more keywords