Non-IDH1-R132H IDH1/2 mutations are associated with increased DNA methylation and improved survival in astrocytomas, compared to IDH1-R132H mutations
Sign Up to like & getrecommendations! Published in 2021 at "Acta Neuropathologica"
DOI: 10.1007/s00401-021-02291-6
Abstract: Somatic mutations in the isocitrate dehydrogenase genes IDH1 and IDH2 occur at high frequency in several tumour types. Even though these mutations are confined to distinct hotspots, we show that gliomas are the only tumour… read more here.
Keywords: r132h; r132h idh1; idh1 r132h; dna methylation ... See more keywords
Combined Diffuse Astrocytoma and Pleomorphic Xanthoastrocytoma Grade III Sharing IDH1 R132H Mutation.
Sign Up to like & getrecommendations! Published in 2018 at "World neurosurgery"
DOI: 10.1016/j.wneu.2018.05.156
Abstract: BACKGROUND Collision tumors are often difficult to distinguish from intratumoral heterogeneity in diffuse gliomas. CASE DESCRIPTION We report the case of a 44-year-old woman admitted for intracranial hypertension. Magnetic resonance imaging revealed a right intra-axial… read more here.
Keywords: grade iii; idh1 r132h; pleomorphic xanthoastrocytoma; mutation ... See more keywords
Frequent false‐negative immunohistochemical staining with IDH1 (R132H)‐specific H09 antibody on frozen section control slides: a potential pitfall in glioma diagnosis
Sign Up to like & getrecommendations! Published in 2019 at "Histopathology"
DOI: 10.1111/his.13756
Abstract: Intraoperative consultation using frozen sections (FSs) is an integral component of clinical practice. As a quality control measure, FS diagnosis is subsequently compared with the findings on a FS control slide. These control slides can… read more here.
Keywords: r132h specific; control; antibody; control slides ... See more keywords
IDH1 Expression via the R132H Mutation–Specific Antibody in Adrenocortical Neoplasias—Prognostic Impact in Carcinomas
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvaa018
Abstract: Abstract Context Mutations to isocitrate dehydrogenase (IDH) appear to play a prognostic or predictive role in several neoplasias. Immunohistochemical staining designed to detect a specific R132H mutation to IDH1 showed expression in the normal adrenal… read more here.
Keywords: carcinomas; staining; adrenocortical tumors; r132h mutation ... See more keywords
IDH1 R132H Mutation Enhances Cell Migration by Activating AKT-mTOR Signaling Pathway, but Sensitizes Cells to 5-FU Treatment as NADPH and GSH Are Reduced
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0169038
Abstract: Aim of study Mutations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) gene were recently discovered in vast majority of World Health Organization (WHO) grade II/III gliomas. This study is to understand the effects… read more here.
Keywords: idh1 r132h; nadph gsh; r132h mutation;
IDH1 R132H predicts sensitivity to Bcl-xL inhibition-mediated programmed cell death
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.23399
Abstract: The anti-apoptotic Bcl-2 family of proteins, such as Bcl-2, Bcl-xL and Mcl-1, are pivotal in cell death regulation in cancer. More than three decades ago, the first of these cell death regulators was identified as… read more here.
Keywords: inhibition; idh1 r132h; cell death; bcl ... See more keywords
Characterization of an IDH1 R132H Rabbit Monoclonal Antibody, MRQ-67, and Its Applications in the Identification of Diffuse Gliomas
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DOI: 10.3390/antib12010014
Abstract: The current diagnosis of diffuse glioma involves isocitrate dehydrogenase (IDH) mutation testing. Most IDH mutant gliomas carry a G-to-A mutation at IDH1 position 395, resulting in the R132H mutant. R132H immunohistochemistry (IHC), therefore, is used… read more here.
Keywords: r132h mutant; idh1 r132h; mutation; mrq ... See more keywords
High EZH2 Protein Expression Is a Poor Prognostic Predictor in IDH1 R132H-Negative Gliomas
Sign Up to like & getrecommendations! Published in 2022 at "Diagnostics"
DOI: 10.3390/diagnostics12102383
Abstract: Accumulating data indicates that enhancer of zeste homology 2 (EZH2) and isocitrate dehydrogenase 1 (IDH1) are implicated in promoting tumourigenesis in a myriad of malignancies including gliomas. We aimed to determine the immunoexpression of EZH2… read more here.
Keywords: ezh2; expression; gliomas; high ezh2 ... See more keywords
Nanomechanical Signatures in Glioma Cells Depend on CD44 Distribution in IDH1 Wild-Type but Not in IDH1R132H Mutant Early-Passage Cultures
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24044056
Abstract: Atomic force microscopy (AFM) recently burst into biomedicine, providing morphological and functional characteristics of cancer cells and their microenvironment responsible for tumor invasion and progression, although the novelty of this assay needs to coordinate the… read more here.
Keywords: cell; idh1; idh1 wild; nanomechanical signatures ... See more keywords
IDH1 R132H Mutation Is Accompanied with Malignant Progression of Paired Primary-Recurrent Astrocytic Tumours
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cancer"
DOI: 10.7150/jca.20665
Abstract: IDH1 R132H mutation is an important marker of survival in patients with gliomas. Although there are many changes of genes in tumour malignant progression, IDH1 R132H mutation status in glioma progression remained unclear. Here, an… read more here.
Keywords: r132h mutation; progression; idh1 r132h; mutation ... See more keywords