BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation
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DOI: 10.1038/nature24294
Abstract: The branched-chain amino acid (BCAA) pathway and high levels of BCAA transaminase 1 (BCAT1) have recently been associated with aggressiveness in several cancer entities. However, the mechanistic role of BCAT1 in this process remains largely… read more here.
Keywords: idhmut; bcat1; dna hypermethylation; stem ... See more keywords
Presenting clinical and radiographic features of diffuse glioma molecular subtypes in accordance with the 2021 CNS5 WHO classification
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DOI: 10.1093/nop/npaf067
Abstract: Background The incorporation of molecular parameters into WHO CNS5 has led to reclassification of gliomas. We describe presenting clinical and radiographic features of diffuse adult gliomas according to CNS5 category. Methods We reviewed pathology reports,… read more here.
Keywords: features diffuse; presenting clinical; idhmut; gbm ... See more keywords
Radiomics and Qualitative Features From Multiparametric MRI Predict Molecular Subtypes in Patients With Lower-Grade Glioma
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DOI: 10.3389/fonc.2021.756828
Abstract: Background Isocitrate dehydrogenase (IDH) mutation and 1p19q codeletion status have been identified as significant markers for therapy and prognosis in lower-grade glioma (LGG). The current study aimed to construct a combined machine learning-based model for… read more here.
Keywords: idhmut; molecular subtypes; grade glioma; model ... See more keywords