BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature24294
Abstract: The branched-chain amino acid (BCAA) pathway and high levels of BCAA transaminase 1 (BCAT1) have recently been associated with aggressiveness in several cancer entities. However, the mechanistic role of BCAT1 in this process remains largely… read more here.
Keywords: idhmut; bcat1; dna hypermethylation; stem ... See more keywords
Radiomics and Qualitative Features From Multiparametric MRI Predict Molecular Subtypes in Patients With Lower-Grade Glioma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.756828
Abstract: Background Isocitrate dehydrogenase (IDH) mutation and 1p19q codeletion status have been identified as significant markers for therapy and prognosis in lower-grade glioma (LGG). The current study aimed to construct a combined machine learning-based model for… read more here.
Keywords: idhmut; molecular subtypes; grade glioma; model ... See more keywords