iDILI: MH-Zellen zur Diagnosestellung geeignet?
Sign Up to like & getrecommendations! Published in 2017 at "Zeitschrift Fur Gastroenterologie"
DOI: 10.1055/s-0042-116995
Abstract: Die Diagnostizierung einer idiosynkratischen arzneimittelinduzierten Leberschadigung („Idiosyncratic Drug-induced Liver Injury“, iDILI) stellt eine grose Herausforderung dar. A. Benesic und Kollegen haben nun untersucht, ob in diesem Zusammenhang Hepatozyten-ahnliche Zellen monozytaren Ursprungs (MH-Zellen) einen positiven Beitrag… read more here.
Keywords: zur diagnosestellung; zellen; idili zellen; diagnosestellung geeignet ... See more keywords
Editor’s Highlight: An Impaired Immune Tolerance Animal Model Distinguishes the Potential of Troglitazone/Pioglitazone and Tolcapone/Entacapone to Cause IDILI
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DOI: 10.1093/toxsci/kfx219
Abstract: We have developed an animal model of amodiaquine-induced liver injury that has characteristics very similar to idiosyncratic drug-induced liver injury (IDILI) in humans by impairing immune tolerance using a PD1-/- mouse and cotreatment with anti-CTLA-4.… read more here.
Keywords: troglitazone; tolcapone; pioglitazone; entacapone ... See more keywords