LCN2 is a new diagnostic biomarker and potential therapeutic target in idiopathic short stature
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17408
Abstract: Idiopathic short stature (ISS) is the most common paediatric endocrine disease. However, the underlying pathology of ISS remains unclear. Currently, there are no effective diagnostic markers or therapeutic strategies available for ISS. In this study,… read more here.
Keywords: new diagnostic; lcn2 new; stature; short stature ... See more keywords
Once-Weekly Administration of Sustained-Release Growth Hormone in Korean Prepubertal Children with Idiopathic Short Stature: A Randomized, Controlled Phase II Study
Sign Up to like & getrecommendations! Published in 2018 at "Hormone Research in Paediatrics"
DOI: 10.1159/000489262
Abstract: Background/Aims: To determine the optimal dose of LB03002, a sustained-release, once-weekly formulation of recombinant human growth hormone (rhGH), and to compare its efficacy and safety with daily rhGH in children with idiopathic short stature (ISS).… read more here.
Keywords: week; children idiopathic; lb03002 week; growth hormone ... See more keywords
A Novel Method for Adult Height Prediction in Children With Idiopathic Short Stature Derived From a German-Dutch Cohort
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvac074
Abstract: Abstract Context Prediction of adult height (AH) is important in clinical management of short children. The conventional methods of Bayley-Pinneau (BP) or Roche-Wainer-Thissen (RWT) have limitations. Objective We aimed to develop a set of algorithms… read more here.
Keywords: short stature; prediction; adult height; idiopathic short ... See more keywords
Characteristics of Gut Microbiome and Its Metabolites, Short-Chain Fatty Acids, in Children With Idiopathic Short Stature
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.890200
Abstract: Background The gut microbiome is important for host nutrition and metabolism. Whether the gut microbiome under normal diet regulate human height remains to be addressed. Our study explored the possible relationship between gut microbiota, its… read more here.
Keywords: gut microbiota; short stature; group; gut microbiome ... See more keywords
Height outcomes in Korean children with idiopathic short stature receiving growth hormone treatment
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.925102
Abstract: Objectives Growth hormone (GH) therapy’s capacity to increase height velocity and height at the end of the study in children with idiopathic short stature (ISS) is controversial. We aimed to investigate the height standard deviation… read more here.
Keywords: short stature; sds; growth hormone; treatment ... See more keywords
Comparative efficacy of aromatase inhibitors and gonadotropin-releasing hormone analogue in increasing final height of idiopathic short stature boys: a network meta-analysis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1167351
Abstract: Objective To investigate the efficacy of monotherapy with AIs or GnRHa in improving the height of boys with idiopathic short stature (ISS). Method We performed a systematic search in Pubmed, The Cochrane Library, Chinese National… read more here.
Keywords: final height; short stature; height; network meta ... See more keywords
Detection of Del/Dup Inside SHOX/PAR1 Region in Children and Young Adults with Idiopathic Short Stature
Sign Up to like & getrecommendations! Published in 2021 at "Genes"
DOI: 10.3390/genes12101546
Abstract: Short stature is a common growth disorder defined as a body height two standard deviations (SD) or more below the mean for a given age, gender, and population. A large part of the cases remains… read more here.
Keywords: children young; detection; stature; short stature ... See more keywords
Heterozygous NPR2 Variants in Idiopathic Short Stature
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13061065
Abstract: Heterozygous variants in the NPR2 gene, which encodes the B-type natriuretic peptide receptor (NPR-B), a regulator of skeletal growth, were reported in 2–6% cases of idiopathic short stature (ISS). Using next-generation sequencing (NGS), we aimed… read more here.
Keywords: npr2 variants; growth; heterozygous npr2; short stature ... See more keywords
The Efficiency of Recombined Growth Hormone Therapy in Idiopathic Short Stature
Sign Up to like & getrecommendations! Published in 2019 at "Revista de Chimie"
DOI: 10.37358/rc.19.2.6957
Abstract: Idiopathic short stature (ISS) deficiency reflects a major public health issue. In Romania the incidence is 1/3000 - 6000 births, with an increased prevalence in boys. ISS is the condition where the height of a… read more here.
Keywords: stature; short stature; growth hormone; idiopathic short ... See more keywords