Investigation of indole biodegradation by Cupriavidus sp. strain IDO with emphases on downstream biotransformation and indigo production
Sign Up to like & getrecommendations! Published in 2021 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-021-14444-x
Abstract: Indole, as a typical N-heterocyclic aromatic pollutant, poses risks to living things; however, indole-biotransformation mechanisms remain under-discussed, especially those related to its downstream biotransformation. Here, we systematically investigated the characteristics of indole degradation by strain… read more here.
Keywords: strain ido; ido; cupriavidus; biotransformation ... See more keywords
Effet in vitro d’un inhibiteur de l’indoléamine 2,3 dioxygénase sur les propriétés cytotoxiques des lymphocytes infiltrant la tumeur (TILs) contre des lignées tumorales de mélanome
Sign Up to like & getrecommendations! Published in 2019 at "Annales De Dermatologie Et De Venereologie"
DOI: 10.1016/j.annder.2019.09.493
Abstract: Introduction Grâce aux progres therapeutiques recents, le pronostic du melanome metastatique s’est transforme. L’immunotherapie est l’un des piliers de cette revolution. Malheureusement, nous nous heurtons a un phenomene d’immunotolerance induit en partie par les cellules… read more here.
Keywords: anti ido; production; par; ido ... See more keywords
Decidual IDO+ macrophage promotes the proliferation and restricts the apoptosis of trophoblasts.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of reproductive immunology"
DOI: 10.1016/j.jri.2021.103364
Abstract: Indoleamine 2, 3-dioxygenase (IDO), a tryptophan-catabolizing enzyme, is essential in physiological immunoregulation. The present research was conducted to elucidate the expression and roles of IDO in decidual macrophages (dMφ) during early pregnancy. Here, we observed… read more here.
Keywords: macrophage promotes; apoptosis; ido; decidual ido ... See more keywords
Cold to Hot: Binary Cooperative Microneedle Array Amplified Photo-Immunotherapy for Eliciting Antitumor Immunity and Abscopal Effect.
Sign Up to like & getrecommendations! Published in 2020 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.0c05090
Abstract: In this study, an ingenious core-shell structure microneedles (CSMNs) array was designed to synergistically boost robust immune response by intralesional co-delivery of photosensitizer and indoleamine 2,3-dioxygenase (IDO) blockade. Photosensitizer indocyanine green was encapsulated into chitosan… read more here.
Keywords: array; antitumor immunity; ido; microneedle ... See more keywords
Kynurenic acid, an IDO metabolite, controls TSG-6-mediated immunosuppression of human mesenchymal stem cells
Sign Up to like & getrecommendations! Published in 2017 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-017-0006-2
Abstract: Mesenchymal stem cells (MSCs) have been demonstrated to be anti-inflammatory against various immune disorders through several factors, including indoleamine 2,3-dioxygenase (IDO) and TNF-stimulated gene 6 (TSG-6). However, little is known about the necessity for both… read more here.
Keywords: kynurenic acid; ido; controls tsg; tsg ... See more keywords
A polymeric IDO inhibitor based on poly(ethylene glycol)-b-poly(L-tyrosine-co-1-methyl-D-tryptophan) enables facile trident cancer immunotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d2bm01181f
Abstract: Indoleamine 2,3-dioxygenase (IDO), with an immunoregulatory effect related to tryptophan metabolism, has emerged as an attractive target for cancer immunotherapy. Here, a polymeric IDO inhibitor based on the poly(ethylene glycol)-b-poly(L-tyrosine-co-1-methyl-D-tryptophan) copolymer (PEG-b-P(Tyr-co-1-MT)) was developed for… read more here.
Keywords: polymeric ido; inhibitor; ido; cancer ... See more keywords
Indoleamine 2, 3-Dioxygenase: A Professional Immunomodulator and Its Potential Functions in Immune Related Diseases.
Sign Up to like & getrecommendations! Published in 2020 at "International reviews of immunology"
DOI: 10.1080/08830185.2020.1836176
Abstract: Indoleamine 2, 3-dioxygenase (IDO) as an intracellular cytosolic enzyme converts tryptophan (Trp) to N-formyl kynurenine which leads to proinflammatory T-cell apoptosis and prevention of immune cells maturation via decreasing the level of cellular energy. Trp… read more here.
Keywords: ido; immune related; related diseases; indoleamine dioxygenase ... See more keywords
Antiviral Effect of IDO in Mouse Fibroblast Cells During Influenza Virus Infection.
Sign Up to like & getrecommendations! Published in 2017 at "Viral immunology"
DOI: 10.1089/vim.2016.0140
Abstract: While upregulation of 2,3-dioxygenase (IDO) accompanied by degradation of tryptophan along the kynurenine pathway have been reported to exert antimicrobial effects against a wide range of infectious agents, its role in the replication of influenza… read more here.
Keywords: mouse fibroblast; ido; infection; influenza virus ... See more keywords
Indoleamine 2,3 dioxygenase (IDO) as a new predictor for advance coronary artery diseases
Sign Up to like & getrecommendations! Published in 2020 at "European Heart Journal"
DOI: 10.1093/ehjci/ehaa946.1295
Abstract: Indoleamine 2,3 dioxygenase (IDO), the rate-limiting enzyme in in the kynurenine (Kyn) pathway of tryptophan (Trp) degradation, is modulated by inflammation and regarded as a key molecule driving immunotolerance and immunosuppressive mechanisms. This response accelerates… read more here.
Keywords: ido; year; cad; coronary artery ... See more keywords
Tryptophan catabolites along the indoleamine 2,3-dioxygenase pathway as a biological link between depression and cancer
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Pharmacology"
DOI: 10.1097/fbp.0000000000000384
Abstract: Both depression and cancer are related to a dysregulation of inflammatory and immune pathways. Indeed, depression is associated with increased expression of interferon-&ggr;, interleukin-1&bgr;, and tumor necrosis factor &agr; (TNF-&agr;). In contrast, reductions of the… read more here.
Keywords: depression; ido; link; cancer ... See more keywords
IDO in MDS/AML disease progression and its role in resistance to azacitidine: a potential new drug target?
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Haematology"
DOI: 10.1111/bjh.16710
Abstract: In this issue, M€ uller-Thomas et al. explored the predictive value of indoleamine 2,3 dioxygenase (IDO) expression in 96 patients with high-risk myelodysplastic syndromes (MDS) and secondary AML (sAML) treated with azacitidine. MDS are clonal… read more here.
Keywords: ido; mds; mds aml; disease progression ... See more keywords