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Published in 2019 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-019-02306-y
Abstract: The prognostic value of the local immune phenotype in patients with colorectal cancer has been extensively studied. Neoadjuvant radiotherapy and/or chemotherapy may potentially influence these immune responses. In this study, we examined the prognostic role…
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Keywords:
ido1;
cd8;
prognostic value;
neoadjuvant chemoradiation ... See more keywords
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Published in 2021 at "Cardiovascular Toxicology"
DOI: 10.1007/s12012-021-09657-y
Abstract: Indoleamine 2,3-dioxygenase 1 (IDO1) is an enzyme for tryptophan metabolism, involved in immune cell differentiation/maturation and cancer biology. IDO1 is also expressed in cardiomyocytes, but its roles in the cardiovascular system are not fully understood.…
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Keywords:
ido1;
cardiac hypertrophy;
pi3k akt;
hypertrophy ... See more keywords
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Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2016.12.029
Abstract: High expression of the immunosuppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO1) for a broad range of malignancies is associated with poor patient prognosis, and the enzyme is a validated target for cancer intervention. To identify novel…
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Keywords:
ido1;
enzyme indoleamine;
dioxygenase ido1;
ido1 inhibitors ... See more keywords
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Published in 2017 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2017.03.012
Abstract: ABSTRACT Indoleamine 2,3‐dioxygenase 1 (IDO1) plays a key role in the immune system by regulating tryptophan levels and T cell differentiation. Several tumor types overexpress IDO1 to avoid immune surveillance making IDO1 of interest as…
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Keywords:
ido1;
aryl hydrocarbon;
indoleamine dioxygenase;
ido1 inhibitors ... See more keywords
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Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01305
Abstract: Indoleamine 2,3-dioxygenase-1 (IDO1) plays an important role in tumor immune escape. However, unsatisfactory clinical efficacies of selective IDO1 inhibitors have impeded their further development, suggesting that they do not exert sufficient antitumor effects by selectively…
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Keywords:
cancer;
ido2;
ido1 ido2;
strategy ... See more keywords
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Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01665
Abstract: Since the discovery of the implication of indoleamine 2,3-dioxygenase 1 (IDO1) in tumoral immune resistance in 2003, the search for inhibitors has been intensely pursued both in academia and in pharmaceutical companies, supported by the…
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Keywords:
indoleamine dioxygenase;
dioxygenase ido1;
ido1;
ido1 structure ... See more keywords
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Published in 2019 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-019-0246-4
Abstract: Indoleamine 2,3-dioxygenase 1 (IDO1) is emerging as a promising therapeutic target for the treatment of malignant tumors characterized by dysregulated tryptophan metabolism. However, the antitumor efficacy of existing small-molecule IDO1 inhibitors is still unsatisfactory, and…
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Keywords:
ido1;
natural products;
indoleamine dioxygenase;
activity ... See more keywords
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Published in 2017 at "MedChemComm"
DOI: 10.1039/c7md00226b
Abstract: Indoleamine 2,3-dioxygenase 1 (IDO1) is considered as an important therapeutic target for the treatment of cancer, chronic infections and other diseases that are associated with immune suppression. Recent developments in understanding the catalytic mechanism of…
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Keywords:
ido1;
ido1 enzyme;
potent compounds;
indoleamine dioxygenase ... See more keywords
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Published in 2019 at "Cell Cycle"
DOI: 10.1080/15384101.2019.1652471
Abstract: ABSTRACT Inflammation and myocardial weakness, two major hallmarks of chronic viral myocarditis (VMC), often lead to dilated cardiomyopathy or chronic heart failure. It has been reported that indoleamine 2,3-dioxygenase-1 (IDO1) may play a pathogenic role…
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Keywords:
ido1;
viral myocarditis;
chronic viral;
inflammatory response ... See more keywords
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Published in 2017 at "Oncoimmunology"
DOI: 10.1080/2162402x.2016.1273310
Abstract: ABSTRACT Indoleamine 2,3-deoxygenase 1 (IDO1) induces immune tolerance in the tumor microenvironment (TME) and is recognized as a potential therapeutic target. We studied the expression of both IDO1 and the related tryptophan 2,3-dioxygenase (TDO) in…
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Keywords:
ido1;
cutaneous cell;
ctcl;
biological clinical ... See more keywords
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Published in 2017 at "OncoImmunology"
DOI: 10.1080/2162402x.2016.1274477
Abstract: ABSTRACT Kynurenine formation by tryptophan-catabolic indoleamine-2,3-dioxygenase 1 (IDO1) plays a key role in tumor immune evasion and inhibition of IDO1 is efficacious in preclinical models of breast cancer. As the response of breast cancer to…
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Keywords:
ido1;
breast cancer;
expression;
promoter ... See more keywords