Synthesis and evaluation of oxindoles as promising inhibitors of the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1.
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DOI: 10.1039/c7md00226b
Abstract: Indoleamine 2,3-dioxygenase 1 (IDO1) is considered as an important therapeutic target for the treatment of cancer, chronic infections and other diseases that are associated with immune suppression. Recent developments in understanding the catalytic mechanism of… read more here.
Keywords: ido1; ido1 enzyme; potent compounds; indoleamine dioxygenase ... See more keywords