Indoleamine 2,3-dioxygenase expression in the prognosis of the localized prostate cancer
Sign Up to like & getrecommendations! Published in 2020 at "International Urology and Nephrology"
DOI: 10.1007/s11255-020-02414-0
Abstract: Background Indoleamine 2,3-dioxygenase (IDO1) is an enzyme that acts as an immunomodulatory molecule. It is found in several types of cancer where it seems to be associated with tumor escape due to its immunosuppressive mechanisms.… read more here.
Keywords: prostate; recurrence; ido1 expression; expression ... See more keywords
Characterization of the temporal, cell-specific and interferon-inducible patterns of indoleamine 2,3 dioxygenase 1 (IDO1) expression in the human placenta across gestation.
Sign Up to like & getrecommendations! Published in 2021 at "Placenta"
DOI: 10.1016/j.placenta.2021.09.008
Abstract: INTRODUCTION The human placenta performs multiple functions necessary for successful pregnancy, but the metabolic pathways and molecular mechanisms responsible for regulating placental development and functions remain incompletely understood. Catabolism of the essential amino acid tryptophan… read more here.
Keywords: expression human; human placenta; ido1 expression; expression ... See more keywords
Investigating the correlation between IDO1/PD-L1 expression or co-expression and EGFR/KRAS gene mutations in advanced NSCLC
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-14768-5
Abstract: Lung cancer was frequently diagnosed at advanced stages (III/IV) and exhibited poor 5-year survival due to limited treatment efficacy. While immunotherapy and targeted therapies had advanced care, drug resistance persisted as a critical challenge. Our… read more here.
Keywords: expression egfr; egfr kras; ido1 expression; advanced nsclc ... See more keywords
Carbidopa, an activator of aryl hydrocarbon receptor, suppresses IDO1 expression in pancreatic cancer and decreases tumor growth
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Journal"
DOI: 10.1042/bcj20210851
Abstract: IDO1 is an immunomodulatory enzyme responsible for tryptophan catabolism. Its expression in immune cells, especially the DCs, has attracted attention because it leads to tryptophan depletion at the immunological synapse, thereby causing T-cell anergy and… read more here.
Keywords: tumor growth; expression; ido1 expression; cancer ... See more keywords
Abstract 142: Integrin α6β4 upregulates IDO1 expression and decreases IFNγ-mediated T cell growth in ER-negative breast cancer
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-142
Abstract: The kynurenine metabolic pathway degrades tryptophan into immunosuppressive metabolites following pro-inflammatory cytokine stimulation and is upregulated in ER-negative (ER(-)) breast cancers, where it is associated with a worse prognosis. The laminin receptor integrin α6β4 is… read more here.
Keywords: expression; breast cancer; ido1 expression; integrin ... See more keywords
Constitutive IDO1 Expression in Human Tumors Is Driven by Cyclooxygenase-2 and Mediates Intrinsic Immune Resistance.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-16-0400
Abstract: Tumors use various mechanisms to avoid immune destruction. Cyclooxygenase-2 (COX-2) expression may be a driver of immune suppression in melanoma, but the mechanisms involved remain elusive. Here, we show that COX-2 expression drives constitutive expression… read more here.
Keywords: expression human; ido1 expression; constitutive ido1; expression ... See more keywords
Platelet Ido1 expression is induced during Plasmodium yoelii infection, altering plasma tryptophan metabolites
Sign Up to like & getrecommendations! Published in 2024 at "Blood Advances"
DOI: 10.1182/bloodadvances.2024013175
Abstract: Key Points • Platelet Ido1 is upregulated in response to IFN-γ including in Plasmodium infection.• Platelets modulate plasma tryptophan metabolites altering kynurenine-to-tryptophan ratios. read more here.
Keywords: tryptophan metabolites; ido1 expression; infection; plasma tryptophan ... See more keywords