Target-binding behavior of IDPs via pre-structured motifs.
Sign Up to like & getrecommendations! Published in 2021 at "Progress in molecular biology and translational science"
DOI: 10.1016/bs.pmbts.2021.07.031
Abstract: Pre-Structured Motifs (PreSMos) are transient secondary structures observed in many intrinsically disordered proteins (IDPs) and serve as protein target-binding hot spots. The prefix "pre" highlights that PreSMos exist a priori in the target-unbound state of… read more here.
Keywords: pre structured; target; idps; target binding ... See more keywords
Intra-chain interaction topology can identify functionally similar Intrinsically Disordered Proteins.
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical journal"
DOI: 10.1016/j.bpj.2020.11.2282
Abstract: Functionally similar IDPs (Intrinsically Disordered Proteins) often have little sequence similarity. This is in stark contrast to folded proteins and poses a challenge for the inverse problem: functional classification of IDPs using sequence alignment. The… read more here.
Keywords: functionally similar; classification; topology; interaction ... See more keywords
Detection and quantification of 2-oxo-histidine-containing dipeptides
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.10.027
Abstract: Imidazole-containing dipeptides (IDPs), such as carnosine and anserine, are found exclusively in various animal tissues, especially in skeletal muscles and nerves. They show antioxidant activity through metal chelating and free radical scavenging mechanisms. However, the… read more here.
Keywords: histidine containing; containing dipeptides; oxo histidine; idps ... See more keywords
Interplay between intrinsically disordered proteins inside membraneless protein liquid dropletsâ€
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Science"
DOI: 10.1039/c9sc03191j
Abstract: Intrinsically disordered proteins (IDPs) in cells phase separate to form diverse membraneless organelles, which have condensed liquid droplet-like properties and often contain multiple IDPs. However, how potential interactions between different IDPs affect the dynamic behavior… read more here.
Keywords: protein; inside droplets; membraneless; idps ... See more keywords
How phosphorylation impacts intrinsically disordered proteins and their function
Sign Up to like & getrecommendations! Published in 2022 at "Essays in Biochemistry"
DOI: 10.1042/ebc20220060
Abstract: Abstract Phosphorylation is the most common post-translational modification (PTM) in eukaryotes, occurring particularly frequently in intrinsically disordered proteins (IDPs). These proteins are highly flexible and dynamic by nature. Thus, it is intriguing that the addition… read more here.
Keywords: intrinsically disordered; disordered proteins; impacts intrinsically; phosphorylation impacts ... See more keywords
Investigating Intrinsically Disordered Proteins With Brownian Dynamics
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.898838
Abstract: Intrinsically disordered proteins (IDPs) have recently become systems of great interest due to their involvement in modulating many biological processes and their aggregation being implicated in many diseases. Since IDPs do not have a stable,… read more here.
Keywords: intrinsically disordered; brownian dynamics; disordered proteins; idps ... See more keywords