IDR‐1018 induces cell proliferation, migration, and reparative gene expression in 2D culture and 3D human skin equivalents
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.2953
Abstract: Skin lesions are associated with functional/cosmetic problems for those afflicted. Scarless regeneration is a challenge, not limited to the skin, and focus of active investigation. Recently, the host defense peptide innate defense regulatory peptide 1018… read more here.
Keywords: idr 1018; human skin; proliferation; expression ... See more keywords
Innate defense regulator IDR-1018 activates human mast cells through G protein-, phospholipase C-, MAPK- and NF-ĸB-sensitive pathways
Sign Up to like & getrecommendations! Published in 2017 at "Immunologic Research"
DOI: 10.1007/s12026-017-8932-0
Abstract: Host defense (antimicrobial) peptides not only display antimicrobial activities against numerous pathogens but also exert a broader spectrum of immune-modulating functions. Innate defense regulators (IDRs) are a class of host defense peptides synthetically developed from… read more here.
Keywords: defense; mast cells; idr 1018; mast ... See more keywords
An Immunomodulatory Peptide Confers Protection in an Experimental Candidemia Murine Model
Sign Up to like & getrecommendations! Published in 2017 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.02518-16
Abstract: ABSTRACT Fungal Candida species are commensals present in the mammalian skin and mucous membranes. Candida spp. are capable of breaching the epithelial barrier of immunocompromised patients with neutrophil and cell-mediated immune dysfunctions and can also… read more here.
Keywords: murine; experimental candidemia; idr 1018; model ... See more keywords
Design of a novel antimicrobial peptide 1018M targeted ppGpp to inhibit MRSA biofilm formation
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DOI: 10.1186/s13568-021-01208-6
Abstract: Methicillin-resistant staphylococcus aureus (MRSA) and its biofilm infection were considered as one of the main international health issues. There are still many challenges for treatment using traditional antibiotics. In this study, a mutant peptide of… read more here.
Keywords: peptide; idr 1018; design novel; ppgpp ... See more keywords
The Combination of Synoeca-MP Antimicrobial Peptide with IDR-1018 Stimulates Proliferation, Migration, and the Expression of Pro-Regenerative Genes in Both Human Skin Cell Cultures and 3D Skin Equivalents
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13050804
Abstract: In skin lesions, the development of microbial infection affects the healing process, increasing morbidity and mortality rates in patients with severe burns, diabetic foot, and other types of skin injuries. Synoeca-MP is an antimicrobial peptide… read more here.
Keywords: cell; skin; proliferation; peptide ... See more keywords