The essential role of guinea pig cytomegalovirus (GPCMV) IE1 and IE2 homologs in viral replication and IE1-mediated ND10 targeting.
Sign Up to like & getrecommendations! Published in 2017 at "Virology"
DOI: 10.1016/j.virol.2017.01.023
Abstract: Guinea pig cytomegalovirus (GPCMV) immediate early proteins, IE1 and IE2, demonstrated structural and functional homologies with human cytomegalovirus (HCMV). GPCMV IE1 and IE2 co-localized in the nucleus with each other, the viral polymerase and guinea… read more here.
Keywords: guinea pig; ie1; gpcmv; ie1 ie2 ... See more keywords
Proteomics analysis reveals a critical role for the WSSV immediate-early protein IE1 in modulating the host prophenoloxidase system
Sign Up to like & getrecommendations! Published in 2022 at "Virulence"
DOI: 10.1080/21505594.2022.2078471
Abstract: ABSTRACT White spot syndrome virus (WSSV) is a large, enveloped, double-stranded DNA virus that threatens shrimp aquaculture worldwide. So far, the mechanisms of WSSV-host interactions are ill-defined. Recent studies have revealed that IE1, an immediate-early… read more here.
Keywords: system; ie1; wssv; analysis ... See more keywords
Human Cytomegalovirus IE1 Impairs Neuronal Migration by Downregulating Connexin 43
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Virology"
DOI: 10.1128/jvi.00313-23
Abstract: Congenital CMV (cCMV) infection causes neurological sequelae in newborns. Recent studies of cCMV pathogenesis in animal models reveal ventriculomegaly and cortical atrophy associated with impaired neural progenitor cell (NPC) proliferation and migration. ABSTRACT Human cytomegalovirus… read more here.
Keywords: neuronal migration; ie1; cx43; infection ... See more keywords
Non-covalent Interaction With SUMO Enhances the Activity of Human Cytomegalovirus Protein IE1
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.662522
Abstract: Viruses interact with the host cellular pathways to optimize cellular conditions for replication. The Human Cytomegalovirus (HCMV) Immediate-Early protein 1 (IE1) is the first viral protein to express during infection. It is a multifunctional and… read more here.
Keywords: protein; covalent interaction; ie1; non covalent ... See more keywords
Identification of the Key Functional Domains of Bombyx mori Nucleopolyhedrovirus IE1 Protein
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231810276
Abstract: The immediate early protein 1 (IE1) acts as a transcriptional activator and is essential for viral gene transcription and viral DNA replication. However, the key regulatory domains of IE1 remain poorly understood. Here, we analyzed… read more here.
Keywords: mori nucleopolyhedrovirus; functional domains; ie1; bombyx mori ... See more keywords
Cross-Species Analysis of Innate Immune Antagonism by Cytomegalovirus IE1 Protein
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14081626
Abstract: The human cytomegalovirus (CMV) immediate early 1 (IE1) protein has evolved as a multifunctional antagonist of intrinsic and innate immune mechanisms. In addition, this protein serves as a transactivator and potential genome maintenance protein. Recently,… read more here.
Keywords: ie1 protein; ie1; rie1; cytomegalovirus ... See more keywords