Trametinib as a promising therapeutic option in alleviating vascular defects in an endothelial KRAS-induced mouse model.
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DOI: 10.1093/hmg/ddac169
Abstract: Somatic activating Kirsten rat sarcoma viral oncogene homologue (KRAS) mutations have been reported in patients with arteriovenous malformations. By producing LSL-Kras (G12D); Cdh5 (PAC)-CreERT2 [iEC-Kras (G12D*)] mice, we hoped to activate KRAS within vascular endothelial… read more here.
Keywords: kras induced; kras g12d; trametinib; iec kras ... See more keywords