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   Articles with "iec mice" as a keyword



Desmoglein 2, but not desmocollin 2, protects intestinal epithelia from injury

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recommendations! Published in 2018 at "Mucosal Immunology"

DOI: 10.1038/s41385-018-0062-z

Abstract: Desmosomes are the least understood intercellular junctions in the intestinal epithelia and provide cell–cell adhesion via the cadherins desmoglein (Dsg)2 and desmocollin (Dsc)2. We studied these cadherins in Crohn’s disease (CD) patients and in newly… read more here.

Keywords: iec mice; dsg2 iec; intestinal epithelia; iec ... See more keywords

Combined Inactivation of TP53 and MIR34A Promotes Colorectal Cancer Development and Progression in Mice Via Increasing Levels of IL6R and PAI1.

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recommendations! Published in 2018 at "Gastroenterology"

DOI: 10.1053/j.gastro.2018.08.011

Abstract: BACKGROUND & AIMS Combined inactivation of the microRNA 34a gene (MIR34A, by methylation) and the TP53 gene (by mutation or deletion) is observed in 50% of colorectal tumors that progress to distant metastases. We studied mice… read more here.

Keywords: iec mice; mir34a; mice; pai1 ... See more keywords

Intestinal Epithelial Expression of MHCII Determines Severity of Chemical, T Cell-Induced, and Infectious Colitis in Mice.

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recommendations! Published in 2020 at "Gastroenterology"

DOI: 10.1053/j.gastro.2020.06.049

Abstract: BACKGROUND & AIMS Intestinal epithelial cells (IECs) provide a barrier that separates the mucosal immune system from the luminal microbiota. IECs constitutively express low levels of major histocompatibility complex (MHC) class II proteins, which are… read more here.

Keywords: mhcii; cell induced; iec mice; colitis ... See more keywords

ORGANIC ANION TRANSPORTER POLYPEPTIDE (OATP) 3A1 AMELIORATES INTESTINAL MUCOSAL DAMAGE IN INFLAMMATORY BOWEL DISEASE

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recommendations! Published in 2024 at "Gastroenterology"

DOI: 10.1053/j.gastro.2023.11.209

Abstract: Inflammatory bowel disease (IBD) is a chronic condition characterised by disruption of the colonic mucosal barrier. OATP3A1/SLCO3A1 is a bile acid efflux transporter, alleviating cholestasis-associated liver injury. However, the functional role and regulational mechanism of… read more here.

Keywords: disease; slco3a1; expression; iec mice ... See more keywords

Intestinal epithelial transcription factor HNF4A protects against microbiota dependent colitis and expansion of Akkermansia muciniphila

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recommendations! Published in 2023 at "Physiology"

DOI: 10.1152/physiol.2023.38.s1.5734521

Abstract: Development of the inflammatory bowel diseases (IBD) has been linked to altered homeostatic relationships between the intestine and the microbiota it harbors. However early preclinical stages of IBD remain poorly understood, especially with respect to… read more here.

Keywords: microbiota; hnf4a; iec mice; hnf4a iec ... See more keywords

Loss of Intestinal SNX27 Promotes Barrier Dysfunction and Inflammatory Responses

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recommendations! Published in 2024 at "Physiology"

DOI: 10.1152/physiol.2024.39.s1.2245

Abstract: SNX27 belongs to the sorting nexin (SNX) family of proteins that play a crucial role in the endocytic pathway. SNX27 carries a unique PDZ domain, mediates recycling of endocytosed transmembrane proteins, and is critical for… read more here.

Keywords: snx27 iec; physiology; iec mice; snx27 ... See more keywords