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   Articles with "iec mice" as a keyword



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Desmoglein 2, but not desmocollin 2, protects intestinal epithelia from injury

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recommendations! Published in 2018 at "Mucosal Immunology"

DOI: 10.1038/s41385-018-0062-z

Abstract: Desmosomes are the least understood intercellular junctions in the intestinal epithelia and provide cell–cell adhesion via the cadherins desmoglein (Dsg)2 and desmocollin (Dsc)2. We studied these cadherins in Crohn’s disease (CD) patients and in newly… read more here.

Keywords: iec mice; dsg2 iec; intestinal epithelia; iec ... See more keywords
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Combined Inactivation of TP53 and MIR34A Promotes Colorectal Cancer Development and Progression in Mice Via Increasing Levels of IL6R and PAI1.

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recommendations! Published in 2018 at "Gastroenterology"

DOI: 10.1053/j.gastro.2018.08.011

Abstract: BACKGROUND & AIMS Combined inactivation of the microRNA 34a gene (MIR34A, by methylation) and the TP53 gene (by mutation or deletion) is observed in 50% of colorectal tumors that progress to distant metastases. We studied mice… read more here.

Keywords: iec mice; mir34a; mice; pai1 ... See more keywords
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Intestinal Epithelial Expression of MHCII Determines Severity of Chemical, T Cell-Induced, and Infectious Colitis in Mice.

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recommendations! Published in 2020 at "Gastroenterology"

DOI: 10.1053/j.gastro.2020.06.049

Abstract: BACKGROUND & AIMS Intestinal epithelial cells (IECs) provide a barrier that separates the mucosal immune system from the luminal microbiota. IECs constitutively express low levels of major histocompatibility complex (MHC) class II proteins, which are… read more here.

Keywords: mhcii; cell induced; iec mice; colitis ... See more keywords

Intestinal epithelial transcription factor HNF4A protects against microbiota dependent colitis and expansion of Akkermansia muciniphila

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recommendations! Published in 2023 at "Physiology"

DOI: 10.1152/physiol.2023.38.s1.5734521

Abstract: Development of the inflammatory bowel diseases (IBD) has been linked to altered homeostatic relationships between the intestine and the microbiota it harbors. However early preclinical stages of IBD remain poorly understood, especially with respect to… read more here.

Keywords: microbiota; hnf4a; iec mice; hnf4a iec ... See more keywords