Overexpression of native IF1 downregulates glucose-stimulated insulin secretion by pancreatic INS-1E cells
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DOI: 10.1038/s41598-020-58411-x
Abstract: We have previously reported that transient knock-down of ATPase inhibitory factor 1 (IF1) by siRNA upregulates ATP levels and subsequently augments insulin secretion in model pancreatic β-cells INS-1E. Here we investigated how long-term IF1-overexpression impacts… read more here.
Keywords: if1; insulin secretion; native if1; stimulated insulin ... See more keywords
The ATPase Inhibitory Factor 1 (IF1) Contributes to the Warburg Effect and Is Regulated by Its Phosphorylation in S39 by a Protein Kinase A-like Activity
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DOI: 10.3390/cancers16051014
Abstract: Simple Summary The ATPase Inhibitory Factor 1 (IF1) plays a prominent role as an inhibitor of mitochondrial ATP synthase. Herein we review the role of IF1 in promoting the Warburg effect and the relevance of… read more here.
Keywords: atpase inhibitory; atp synthase; if1; inhibitory factor ... See more keywords