Ifenprodil tartrate treatment of adolescents with post-traumatic stress disorder: A double-blind, placebo-controlled trial
Sign Up to like & getrecommendations! Published in 2022 at "Psychiatry Research"
DOI: 10.1016/j.psychres.2022.114486
Abstract: BACKGROUND Several lines of evidence suggest that glutamatergic neurotransmission via the N-methyl-D-aspartate (NMDA) receptor plays a role in certain behavioral manifestations common to Post-Traumatic Stress Disorder (PTSD). Ifenprodil tartrate is a neuroprotective agent that binds… read more here.
Keywords: post traumatic; traumatic stress; ifenprodil; stress disorder ... See more keywords
Ifenprodil Stereoisomers: Synthesis, Absolute Configuration, and Correlation with Biological Activity.
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DOI: 10.1021/acs.jmedchem.0c01912
Abstract: Ifenprodil (1) is a potent GluN2B-selective N-methyl-d-aspartate (NMDA) receptor antagonist that is used as a cerebral vasodilator and has been examined in clinical trials for the treatment of drug addiction, idiopathic pulmonary fibrosis, and COVID-19.… read more here.
Keywords: configuration; ifenprodil; ifenprodil stereoisomers; glun2b nmda ... See more keywords
Development and Validation of [3H]OF-NB1 for Preclinical Assessment of GluN1/2B Candidate Drugs
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DOI: 10.3390/ph15080960
Abstract: GluN2B-enriched N-methyl-D-aspartate receptors (NMDARs) are implicated in several neurodegenerative and psychiatric diseases, such as Alzheimer’s disease. No clinically valid GluN1/2B therapeutic exists due to a lack of selective GluN2B imaging tools, and the state-of-the-art [3H]ifenprodil… read more here.
Keywords: development validation; ifenprodil; nb1 preclinical; preclinical assessment ... See more keywords