IFI16 Impacts Metabolic Reprogramming during Human Cytomegalovirus Infection
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DOI: 10.1128/mbio.00435-22
Abstract: Human cytomegalovirus (HCMV) gathers all the substrates and enzymes necessary for the assembly of new virions from its host cell. For instance, HCMV is known to induce cellular metabolism of infected cells to favor virion… read more here.
Keywords: metabolism; infection; hcmv; human cytomegalovirus ... See more keywords
The Nuclear DNA Sensor IFI16 Indiscriminately Binds to and Diminishes Accessibility of the HSV-1 Genome to Suppress Infection
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DOI: 10.1128/msystems.00198-22
Abstract: Mammalian host defense against viral infection includes broad-acting cellular restriction factors, as well as effectors of intrinsic and innate immunity. IFI16 is a critical nuclear host defense factor and intrinsic immune protein involved in binding… read more here.
Keywords: dna; viral dna; infection; expression ... See more keywords
Toll-like receptor 4-mediated inflammation triggered by extracellular IFI16 is enhanced by lipopolysaccharide binding
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DOI: 10.1371/journal.ppat.1008811
Abstract: Damage-associated molecular patterns (DAMPs) are endogenous molecules activating the immune system upon release from injured cells. Here we show that the IFI16 protein, once freely released in the extracellular milieu of chronically inflamed tissues, can… read more here.
Keywords: ifi16; toll like; inflammation; like receptor ... See more keywords
IFI16 Can Be Used as a Biomarker for Diagnosis of Renal Cell Carcinoma and Prediction of Patient Survival
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DOI: 10.3389/fgene.2021.599952
Abstract: The incidences of renal cell carcinoma (RCC) increase in number each year and account for about 2–3% of all malignant tumors. Many patients have metastasis by the time of diagnosis, and their prognosis is poor.… read more here.
Keywords: ifi16; renal cell; diagnosis; ifi16 expression ... See more keywords
Interferon-induced protein 16 expression in colorectal cancer and its correlation with proliferation and immune signature markers
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DOI: 10.3892/ol.2021.12948
Abstract: Interferon-induced protein 16 (IFI16) is important for innate immune recognition of foreign/damaged DNA. Abnormal IFI16 expression is closely related to the occurrence of multiple malignant tumours, but its expression pattern in colorectal cancer (CRC) remains… read more here.
Keywords: ifi16; proliferation; correlation; expression ... See more keywords