Comprehensive assessment of the association between genes on JAK-STAT pathway (IFIH1, TYK2, IL-10) and systemic lupus erythematosus: a meta-analysis
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Dermatological Research"
DOI: 10.1007/s00403-018-1858-0
Abstract: Previous studies have reported that genes relating to JAK-STAT pathway (IFIH1, TYK2 and IL-10) conferred the susceptibility to SLE. In this study, we performed a meta-analysis (including 43 studies) to evaluate the association between IFIH1… read more here.
Keywords: ifih1; stat pathway; sle; jak stat ... See more keywords
An open-label trial of JAK 1/2 blockade in progressive IFIH1-associated neuroinflammation
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DOI: 10.1212/wnl.0000000000004921
Abstract: IFIH1 gain-of-function causes a spectrum of neuroinflammatory phenotypes associated with enhanced type I interferon production and Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway activation.1,2 Patients most often present in infancy, variably exhibiting… read more here.
Keywords: ifih1; label trial; jak; jak blockade ... See more keywords
Association Among MIF, IFIH1, and IL6 Gene Polymorphisms and Non-Segmental Vitiligo in a Chinese Han Population
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DOI: 10.2147/ccid.s369418
Abstract: Objective The aim of the present study was to investigate the association of single-nucleotide polymorphisms (SNPs) in the macrophage migration inhibiting factor (MIF), interferon-induced Helicase C domain 1 (IFIH1), interleukin-6 (IL6) genes, circulating levels with… read more here.
Keywords: il6; gene polymorphisms; ifih1; segmental vitiligo ... See more keywords
Polymorphisms in ACE1, TMPRSS2, IFIH1, IFNAR2, and TYK2 Genes Are Associated with Worse Clinical Outcomes in COVID-19
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DOI: 10.3390/genes14010029
Abstract: Although advanced age, male sex, and some comorbidities impact the clinical course of COVID-19, these factors only partially explain the inter-individual variability in disease severity. Some studies have shown that genetic polymorphisms contribute to COVID-19… read more here.
Keywords: ifnar2; risk; polymorphisms ace1; ifih1 ... See more keywords