Various interferon (IFN)-inducible transmembrane (IFITM) proteins for COVID-19, is there a role for the combination of mycophenolic acid and interferon?
Sign Up to like & getrecommendations! Published in 2020 at "Biochimie"
DOI: 10.1016/j.biochi.2020.08.006
Abstract: Abstract Various interferon (IFN)-inducible transmembrane (IFITM) proteins are known to be expressed in human tissues though only IFITM 1–3 are inducible by IFN. Numerous studies have shown that activation of IFITM3 could suppress infection by… read more here.
Keywords: ifitm proteins; various interferon; interferon; interferon ifn ... See more keywords
Host antiviral protein IFITM2 restricts pseudorabies virus replication
Sign Up to like & getrecommendations! Published in 2020 at "Virus Research"
DOI: 10.1016/j.virusres.2020.198105
Abstract: Pseudorabies virus (PRV) is one of the most destructive swine pathogens and leads to huge economic losses to the global pig industry. Type I interferons (IFNs) plays a pivotal role in the innate immune response… read more here.
Keywords: antiviral protein; ifitm proteins; host antiviral; infection ... See more keywords
ABHD16A Negatively Regulates the Palmitoylation and Antiviral Function of IFITM Proteins
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DOI: 10.1128/mbio.02289-22
Abstract: IFITM protein is the cells first line of antiviral defense that blocks early stages of viral replication; the underlying mechanism might be associated with the proper distribution in cells. The palmitoylation/depalmitoylation cycle can dynamically regulate… read more here.
Keywords: function; ifitm; palmitoylation depalmitoylation; ifitm proteins ... See more keywords
Caveats of Using Overexpression Approaches to Screen Cellular Host IFITM Proteins for Antiviral Activity
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DOI: 10.3390/pathogens12040519
Abstract: Ectopic protein overexpression in immortalised cell lines is a commonly used method to screen host factors for their antiviral activity against different viruses. However, the question remains as to what extent such artificial protein overexpression… read more here.
Keywords: ifitm proteins; overexpression; antiviral activity; protein ... See more keywords