Construction, expression and antiviral activity analysis of recombinant adenovirus expressing human IFITM3 in vitro
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Biological Macromolecules"
DOI: 10.1016/j.ijbiomac.2019.03.161
Abstract: Abstract Interferon-inducible transmembrane protein 3 (IFITM3) inhibits the replication of multiple pathogenic viruses by blocking their entry. In this study, we constructed a shuttle plasmid, harboring human IFITM3. Thereafter, recombinant adenovirus rAd5-IFITM3 was obtained by… read more here.
Keywords: recombinant adenovirus; infection; human ifitm3; rad5 ifitm3 ... See more keywords
ACE2 Affects the Expression and Function of IFITM3 During SARS-CoV-2 Pseudovirus Infection in Vero E6 Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Viral immunology"
DOI: 10.1089/vim.2022.0042
Abstract: COVID-19 is a globally infectious viral epidemic of great public health concern caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Angiotensin-converting enzyme 2 (ACE2) plays its role as the receptor for SARS-CoV-2 through binding… read more here.
Keywords: infection; vero cells; expression; ifitm3 ... See more keywords
Abstract 3317: IFITM3: A predictive biomarker for therapeutic outcomes in advanced hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-3317
Abstract: Hepatocellular carcinoma (HCC) is a major global health challenge, with China bearing a significant burden due to its high incidence and mortality rates. Vascular invasion (VI), particularly microvascular invasion (MVI), is a critical prognostic factor… read more here.
Keywords: cancer; therapeutic outcomes; analysis; ifitm3 ... See more keywords
IFITM3-Mediated Regulation of Cell Membrane Dynamics Is Essential for Malignant B-Cell Transformation
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-117472
Abstract: Background & Hypothesis: B cell receptor (BCR) signaling and oncogenic tyrosine kinases that mimic BCR-signaling in B-lineage leukemia and lymphoma depend on assembly of membrane proximal signaling complexes. Signalosomes in normal BCR- and oncogene (e.g.… read more here.
Keywords: bcr; cell membrane; lipid rafts; cell ... See more keywords
Identification of a Conserved Intracellular Loop (CIL) Structure That Scaffolds PIP3 to Amplify Oncogenic Signaling during Malignant B-Cell Transformation
Sign Up to like & getrecommendations! Published in 2021 at "Blood"
DOI: 10.1182/blood-2021-149646
Abstract: Background: Within seconds of antigen-encounter, B-cell receptor (BCR) signaling induces dramatic changes of cell membrane lipid composition, including >40-fold increases of local PIP3-concentrations within lipid rafts. While several structural elements, including pleckstrin homology (PH) domains… read more here.
Keywords: activation; pip3; ifitm3; transformation ... See more keywords
Association of IFITM3 with the efficacy of anti-PD1/PD-L1 therapy and regulation of immunosensitivity via MHC-I regulation in SCLC.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2025.43.16_suppl.8105
Abstract: 8105 Background: Majority of small cell lung cancer (SCLC) patients exhibit resistance to immune checkpoint inhibitors (ICIs), which is associated with the downregulation of major histocompatibility complex class I (MHC-I) molecules. This study investigates the… read more here.
Keywords: ifitm3 expression; ifitm3; association ifitm3; regulation ... See more keywords
Development of a chicken interferon-induced transmembrane protein 3 (IFITM3)-specific monoclonal antibody using phage display.
Sign Up to like & getrecommendations! Published in 2022 at "Acta veterinaria Hungarica"
DOI: 10.1556/004.2022.00009
Abstract: Interferon-induced transmembrane protein 3 (IFITM3) has potent antiviral activity against several viruses. Recent studies have reported that the chicken IFITM3 gene also plays a pivotal role in blocking viral replication, but these studies are considerably… read more here.
Keywords: chicken ifitm3; ifitm3 protein; ifitm3; antibody ... See more keywords
Human IFITM3 restricts chikungunya virus and Mayaro virus infection and is susceptible to virus-mediated counteraction
Sign Up to like & getrecommendations! Published in 2021 at "Life Science Alliance"
DOI: 10.26508/lsa.202000909
Abstract: Endogenous and heterologpusly expressed human IFITM3 restricts early and late replication steps of chikungunya and Mayaro virus infection and is downregulated at the protein level in infected cells. Interferon-induced transmembrane (IFITM) proteins restrict membrane fusion… read more here.
Keywords: counteraction; mayaro virus; infection; virus infection ... See more keywords
Interferon-Induced Transmembrane Protein 3 Shapes an Inflamed Tumor Microenvironment and Identifies Immuno-Hot Tumors
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.704965
Abstract: Interferon-induced transmembrane protein 3 (IFITM3) is an interferon-induced membrane protein, which has been identified as a functional gene in multiple human cancers. The role of IFITM3 in cancer has been preliminarily summarized, but its relationship… read more here.
Keywords: addition; interferon induced; induced transmembrane; transmembrane protein ... See more keywords
IFITM3 Interacts with the HBV/HDV Receptor NTCP and Modulates Virus Entry and Infection
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14040727
Abstract: The Na+/taurocholate co-transporting polypeptide (NTCP, gene symbol SLC10A1) is both a physiological bile acid transporter and the high-affinity hepatic receptor for the hepatitis B and D viruses (HBV/HDV). Virus entry via endocytosis of the virus/NTCP… read more here.
Keywords: infection; hbv hdv; virus entry; ifitm3 ... See more keywords