Endogenous IFN‐γ facilitates Pneumocystis infection and downregulates carbohydrate receptors in CD4+ T cell‐depleted mice
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DOI: 10.1002/1873-3468.14875
Abstract: IFN‐γ plays a critical role in host defense against intracellular pathogens. IFN‐γ is produced in the bronchoalveolar lavage fluid of mice infected with Pneumocystis, but the role of IFN‐γ in host defense against Pneumocystis remains… read more here.
Keywords: cd4 cell; cell depleted; endogenous ifn; facilitates pneumocystis ... See more keywords
Neurotoxic Microglial Activation via IFNγ‐Induced Nrf2 Reduction Exacerbating Alzheimer's Disease
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DOI: 10.1002/advs.202304357
Abstract: Microglial neuroinflammation appears to be neuroprotective in the early pathological stage, yet neurotoxic, which often precedes neurodegeneration in Alzheimer's disease (AD). However, it remains unclear how the microglial activities transit to the neurotoxic state during… read more here.
Keywords: alzheimer disease; proinflammatory microglia; neurotoxic microglial; activation ... See more keywords
MxA mRNA decrease preceding NAb detection in IFNβ‐treated MS patients
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DOI: 10.1002/brb3.644
Abstract: Multiple sclerosis (MS) patients treated with interferon beta (IFNβ) are at risk of a declining response to treatment because of the production of IFNβ‐neutralizing antibodies (NAbs). The expression of Myxovirus resistance protein A (MxA) mRNA… read more here.
Keywords: preceding nab; mxa mrna; ifn; decrease preceding ... See more keywords
PARP7i Clinical Candidate RBN‐2397 Exerts Antiviral Activity by Modulating Interferon‐β Associated Innate Immune Response in Macrophages
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DOI: 10.1002/ddr.70013
Abstract: Polyadenosine diphosphate‐ribose polymerase 7 (PARP7) acts as a suppressor of the type I interferon (IFN) signaling pathway via suppressing TANK‐binding protein 1 (TBK1). Research study indicates that inhibition of PARP7 could potentially regulate tumor immunity.… read more here.
Keywords: candidate rbn; interferon; clinical candidate; rbn 2397 ... See more keywords
IFN‐γ stimulates CpG‐induced IL‐10 production in B cells via p38 and JNK signalling pathways
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DOI: 10.1002/eji.201847578
Abstract: The production of IL‐10, a potent immunosuppressive cytokine, must be strictly regulated to ensure a balanced immune response. IFN‐γ, a key cytokine in multiple immune processes and pathologies, is known as an inhibitor of IL‐10… read more here.
Keywords: p38 jnk; production; induced production; ifn ... See more keywords
Type I interferons provide additive signals for murine regulatory B cell induction by Schistosoma mansoni eggs
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DOI: 10.1002/eji.201847858
Abstract: The helminth Schistosoma mansoni (S. mansoni) induces a network of regulatory immune cells, including interleukin (IL)‐10‐producing regulatory B cells (Bregs). However, the signals required for the development and activation of Bregs are not well characterized.… read more here.
Keywords: mansoni; type interferons; ifn; schistosoma mansoni ... See more keywords
Type I interferon signaling deficiency results in dysregulated innate immune responses to SARS‐CoV‐2 in mice
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202249913
Abstract: SARS‐CoV‐2 is a newly emerged coronavirus, causing the global pandemic of respiratory coronavirus disease (COVID‐19). The type I interferon (IFN) pathway is of particular importance for anti‐viral defense and recent studies identified that type I… read more here.
Keywords: ifn; innate immune; responses sars; type interferon ... See more keywords
Persistently active interferon-γ pathway and expansion of T-bet+ B cells in a subset of patients with childhood-onset systemic lupus erythematosus.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202250319
Abstract: Systemic lupus erythematosus (SLE) is an autoimmune disease causing significant morbidity and mortality, despite important improvements in its management in the last decades. The objective of this work is to investigate the role of IFN-γ… read more here.
Keywords: lupus erythematosus; ifn; systemic lupus; bet ... See more keywords
Ubiquitination network in the Type I interferon-induced antiviral signaling pathway.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202350384
Abstract: Type I interferon (IFN-I) is the body's first line of defense against pathogen infection. IFN-I can induce cellular antiviral responses and therefore plays a key role in driving antiviral innate and adaptive immunity. Canonical IFN-I… read more here.
Keywords: antiviral signaling; ifn; induced antiviral; type interferon ... See more keywords
The medulla controls effector primed γδT-Cell developmenti in the adult mouse thymus.
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DOI: 10.1002/eji.202350388
Abstract: γδT cells are produced in the thymus throughout life and provide immunity at epithelial‐rich sites. Unlike conventional αβT cells, γδT‐cell development involves intrathymic acquisition of effector function, with priming for either IL17 or IFN‐γ production… read more here.
Keywords: cell; thymus; ifn; effector ... See more keywords
Age‐related transcript changes in type I interferon signaling in children and adolescents with long COVID
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DOI: 10.1002/eji.202350682
Abstract: SARS‐CoV‐2 typically causes mild symptoms in children, but evidence suggests that persistent immunopathological changes may lead to long COVID (LC). To explore the interplay between LC and innate immunity, we assessed the type I interferon… read more here.
Keywords: age; ifn ifn; children adolescents; type interferon ... See more keywords