MxA mRNA decrease preceding NAb detection in IFNβ‐treated MS patients
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DOI: 10.1002/brb3.644
Abstract: Multiple sclerosis (MS) patients treated with interferon beta (IFNβ) are at risk of a declining response to treatment because of the production of IFNβ‐neutralizing antibodies (NAbs). The expression of Myxovirus resistance protein A (MxA) mRNA… read more here.
Keywords: preceding nab; mxa mrna; ifn; decrease preceding ... See more keywords
IFN‐γ stimulates CpG‐induced IL‐10 production in B cells via p38 and JNK signalling pathways
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DOI: 10.1002/eji.201847578
Abstract: The production of IL‐10, a potent immunosuppressive cytokine, must be strictly regulated to ensure a balanced immune response. IFN‐γ, a key cytokine in multiple immune processes and pathologies, is known as an inhibitor of IL‐10… read more here.
Keywords: p38 jnk; production; induced production; ifn ... See more keywords
Type I interferons provide additive signals for murine regulatory B cell induction by Schistosoma mansoni eggs
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DOI: 10.1002/eji.201847858
Abstract: The helminth Schistosoma mansoni (S. mansoni) induces a network of regulatory immune cells, including interleukin (IL)‐10‐producing regulatory B cells (Bregs). However, the signals required for the development and activation of Bregs are not well characterized.… read more here.
Keywords: mansoni; type interferons; ifn; schistosoma mansoni ... See more keywords
Type I interferon signaling deficiency results in dysregulated innate immune responses to SARS‐CoV‐2 in mice
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DOI: 10.1002/eji.202249913
Abstract: SARS‐CoV‐2 is a newly emerged coronavirus, causing the global pandemic of respiratory coronavirus disease (COVID‐19). The type I interferon (IFN) pathway is of particular importance for anti‐viral defense and recent studies identified that type I… read more here.
Keywords: ifn; innate immune; responses sars; type interferon ... See more keywords
Persistently active interferon-γ pathway and expansion of T-bet+ B cells in a subset of patients with childhood-onset systemic lupus erythematosus.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202250319
Abstract: Systemic lupus erythematosus (SLE) is an autoimmune disease causing significant morbidity and mortality, despite important improvements in its management in the last decades. The objective of this work is to investigate the role of IFN-γ… read more here.
Keywords: lupus erythematosus; ifn; systemic lupus; bet ... See more keywords
Ubiquitination network in the Type I interferon-induced antiviral signaling pathway.
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DOI: 10.1002/eji.202350384
Abstract: Type I interferon (IFN-I) is the body's first line of defense against pathogen infection. IFN-I can induce cellular antiviral responses and therefore plays a key role in driving antiviral innate and adaptive immunity. Canonical IFN-I… read more here.
Keywords: antiviral signaling; ifn; induced antiviral; type interferon ... See more keywords
The medulla controls effector primed γδT-Cell developmenti in the adult mouse thymus.
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DOI: 10.1002/eji.202350388
Abstract: γδT cells are produced in the thymus throughout life and provide immunity at epithelial‐rich sites. Unlike conventional αβT cells, γδT‐cell development involves intrathymic acquisition of effector function, with priming for either IL17 or IFN‐γ production… read more here.
Keywords: cell; thymus; ifn; effector ... See more keywords
IFN‐γ‐mediated inhibition of lung cancer correlates with PD‐L1 expression and is regulated by PI3K‐AKT signaling
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DOI: 10.1002/ijc.31357
Abstract: IFN‐γ plays a crucial role in anti‐tumor responses and also induces expression of PD‐L1, a well‐established inhibitor of anti‐tumor immune function. Understanding how molecular signaling regulates the function of IFN‐γ might improve its anti‐tumor efficacy.… read more here.
Keywords: ifn; pi3k akt; anti tumor; expression ... See more keywords
High Mobility Group Box 1 Mediates Interferon‐γ‐Induced Phenotypic Modulation of Vascular Smooth Muscle Cells
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DOI: 10.1002/jcb.25682
Abstract: The phenotypic modulation of VSMCs is a key cellular event driving neointimal formation and vascular remodeling. As a multifaceted cytokine of cell‐mediated immunity, IFN‐γ has been shown to play a critical role in the pathogenesis… read more here.
Keywords: hmgb1; modulation; ifn; phenotypic modulation ... See more keywords
Frontline Science: Estrogen‐related receptor γ increases poly(I:C)‐mediated type I IFN expression in mouse macrophages
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DOI: 10.1002/jlb.2hi1219-762r
Abstract: Although type I IFNs (IFN‐I) are important for the innate and adaptive immune responses to suppress viral replication, prolonged IFN‐I signaling in macrophages suppresses the immune response. Nuclear receptor estrogen‐related receptor γ (ERRγ) regulates the… read more here.
Keywords: expression; related receptor; poly mediated; estrogen related ... See more keywords
Dysregulation of the IFN‐I signaling pathway by Mycobacterium tuberculosis leads to exacerbation of HIV‐1 infection of macrophages
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DOI: 10.1002/jlb.4ma0422-730r
Abstract: While tuberculosis (TB) is a risk factor in HIV‐1‐infected individuals, the mechanisms by which Mycobacterium tuberculosis (Mtb), the agent of TB in humans, worsens HIV‐1 pathogenesis still need to be fully elucidated. Recently, we showed… read more here.
Keywords: mycobacterium tuberculosis; ifn; hiv; hiv infection ... See more keywords