PASylated interferon &agr; efficiently suppresses hepatitis B virus and induces anti‐HBs seroconversion in HBV‐transgenic mice
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DOI: 10.1016/j.antiviral.2018.11.003
Abstract: ABSTRACT Interferon &agr; (IFN&agr;) so far is the only therapeutic option for chronic hepatitis B virus (HBV) infection that can lead to virus clearance. Unfortunately, its application is limited by side effects and response rates… read more here.
Keywords: agr; hbv transgenic; ifn agr; mifn agr ... See more keywords
Antitumor activity of recombinant RGD-IFN-α2a-core fusion protein in vitro
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DOI: 10.1097/cad.0000000000000421
Abstract: Interferon (IFN) regulates immune responses and antitumor activity. Arginine–glycine–aspartic acid (RGD) peptides can specifically bind to integrin &agr;v&bgr;3, a transmembrane receptor that is highly expressed on the surface of various cancer cells. In this study,… read more here.
Keywords: core fusion; rgd ifn; ifn agr;
Tolerability, pharmacokinetics and antiviral activity of rHSA/IFN&agr;2a for the treatment of chronic hepatitis B infection
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DOI: 10.1111/bcp.13184
Abstract: Aims A recombinant human serum albumin‐interferon alpha2a fusion protein (rHSA/IFN&agr;2a) is expected to extend the half‐life of IFN&agr;2a. This study aims to evaluate the tolerability, safety and efficacy of rHSA/IFN&agr;2a. Methods This is an open,… read more here.
Keywords: rhsa ifn; treatment; ifn; ifn agr ... See more keywords