IFNα-blockade during ART-treated SIV infection lowers tissue vDNA, rescues immune function, and improves overall health.
Sign Up to like & getrecommendations! Published in 2022 at "JCI insight"
DOI: 10.1172/jci.insight.153046
Abstract: Type I interferons (TI-IFNs) drive immune effector functions during acute viral infections and regulate cell cycling and systemic metabolism. That said, chronic TI-IFN signaling in the context of antiretroviral therapy (ART)-treated HIV infection also facilitates… read more here.
Keywords: ifn; ifn blockade; art treated; siv infection ... See more keywords
IFNγ blockade in capillary leak site improves tumour chemotherapy by inhibiting lactate-induced endocytosis of vascular endothelial-cadherins
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.78248
Abstract: IFNγ has long been recognised as a key mediator of tumour immunity and angiostasis. However, IFNγ modulation for cancer therapy is still unsuccessful due to its complex effects on various host cells. In this study,… read more here.
Keywords: ifn blockade; endocytosis vascular; blockade capillary; site ... See more keywords