Grass carp (Ctenopharyngodon idella) GPATCH3 initiates IFN 1 expression via the activation of STING-IRF7 signal axis.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental and comparative immunology"
DOI: 10.1016/j.dci.2020.103781
Abstract: GPATCH3, a protein with G-patch domain, is known to participate in innate immune response and organ development in mammals. However, there are few reports on GPATCH3 in fish. Here the cDNA sequence of GPATCH3 was… read more here.
Keywords: ifn expression; cigpatch3; expression; ctenopharyngodon idella ... See more keywords
Infection by bovine alphaherpesvirus types 1 and 5 induces IFN-λ3 expression in neuronal-type cells and bovine neural tissues.
Sign Up to like & getrecommendations! Published in 2022 at "Veterinary immunology and immunopathology"
DOI: 10.1016/j.vetimm.2022.110391
Abstract: Type III interferons (IFNs) are components of the innate immunity, with IFN lambda- (λ)3 having the most potent bioactivity in humans. IFN-λ has a predominant role in epithelial cells. However, antiviral function in certain infections… read more here.
Keywords: type cells; neural tissues; neuronal type; ifn expression ... See more keywords
Sustained IFN-I Expression during Established Persistent Viral Infection: A “Bad Seed” for Protective Immunity
Sign Up to like & getrecommendations! Published in 2017 at "Viruses"
DOI: 10.3390/v10010012
Abstract: Type I interferons (IFN-I) are one of the primary immune defenses against viruses. Similar to all other molecular mechanisms that are central to eliciting protective immune responses, IFN-I expression is subject to homeostatic controls that… read more here.
Keywords: seed; established persistent; infection; ifn expression ... See more keywords