Outcomes and Challenges of Manufacturing Virus-Specific Cytotoxic T-lymphocytes Using IFN-gamma Cytokine Capture System
Sign Up to like & getrecommendations! Published in 2020 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2020.03.092
Abstract: Background & Aim Background Viral infection/reactivation after allogeneic hematopoietic stem cell (HSCT) or solid organ transplant (SOT) is a significant cause of morbidity and mortality in drug-refractory patients. Adoptive transfer of allogeneic virus-specific cytotoxic T… read more here.
Keywords: specific cytotoxic; using ifn; ifn gamma; virus specific ... See more keywords
Enhancing the potency of human mesenchymal stromal cells in acute Graft versus Host Disease; role for IFN-gamma and cyclosporine A
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DOI: 10.1016/j.jcyt.2020.03.133
Abstract: Background & Aim Mesenchymal stromal cells (MSC) have been approved for use in Crohn's fistula and paediatric acute GvHD and have been tested in clinical trials for organ transplantation. Patients with these inflammatory conditions are… read more here.
Keywords: mesenchymal stromal; potency; csa; msc ... See more keywords
Diagnosis of NTM active infection in lymphadenopathy patients with anti-interferon-gamma auto-antibody using inhibitory ELISA vs. indirect ELISA
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DOI: 10.1038/s41598-020-65933-x
Abstract: The anti-interferon-gamma (IFN-gamma) autoantibody is a known cause of opportunistic non-tuberculous mycobacterial (NTM) infection in adults. Diagnosis of those patients is difficult due to the low sensitivity of bacterial culture, and because detection of the… read more here.
Keywords: diagnosis; infection; ntm infection; inhibitory elisa ... See more keywords
AB1063 CASE SERIES OF PATIENTS WITH CHRONIC NON-TUBERCULOSIS MYCOBACTERIA ACCOMPANYING WITH ANTI-INTERFERON GAMMA ANTIBODY
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DOI: 10.1136/annrheumdis-2020-eular.6610
Abstract: Background: Anti-interferon (IFN) gamma antibody was a rare autoantibody which mainly been reported in Asia. It interferes the interferon pathway and eradication of intracellular pathogens, such as Salmonella or Mycobacteria. This rare disease should be… read more here.
Keywords: gamma; ifn gamma; case; gamma antibody ... See more keywords
226 Checkpoint blockade hastens a switch from an NKT dominant, TNF-alpha-driven to a CD4+/CD8+ IFN-gamma-driven immune response within MC-38 tumor-infiltrating lymphocytes
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DOI: 10.1136/jitc-2020-sitc2020.0226
Abstract: Background It is incompletely understood which populations of tumor-infiltrating lymphocytes (TIL) respond to checkpoint blockade (CB) and when. Recent studies in murine MC-38 colon carcinoma demonstrate CD4+ T cells are among the most prominent responders,1… read more here.
Keywords: cd4 cd8; tnf alpha; blockade; ifn gamma ... See more keywords
Pelareorep to promote the expression of a IFN-gamma-related gene signature that predicts response to checkpoint blockade therapy.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.3089
Abstract: 3089Background: A clinical study in patients (pts) with metastatic breast cancer (mBC) treated with pelareorep resulted in significant improvements in overall survival. Clinical studies with checkp... read more here.
Keywords: gamma related; expression ifn; promote expression; pelareorep promote ... See more keywords
Expression pattern and clinical significance of microRNA-let-7a and IFN-gamma in placental tissue of patients with preeclampsia with severe features
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DOI: 10.1515/jpm-2021-0133
Abstract: Abstract Objectives Preeclampsia with severe features (PECsf) is a common disease in pregnant women. let-7a and IFN-gamma (interferon-gamma) are involved in diagnosis and prognosis of preeclampsia. This study explored effects of let-7a and IFN-gamma on… read more here.
Keywords: let ifn; group; ifn gamma; placental tissue ... See more keywords
Bacteriocin BacSp222 and Its Succinylated Forms Exhibit Proinflammatory Activities Toward Innate Immune Cells
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DOI: 10.2147/jir.s362066
Abstract: Purpose The zoonotic opportunistic pathogen Staphylococcus pseudintermedius 222 produces BacSp222 – an atypical peptide exhibiting the features of a bacteriocin, a virulence factor, and a molecule modulating the host inflammatory reaction. The peptide is secreted… read more here.
Keywords: tnf alpha; bacteriocin bacsp222; exhibit proinflammatory; bacsp222 succinylated ... See more keywords
Interferon-gamma Release Assay Results Are Reliable for Screening for Latent Tuberculosis in Antineutrophil Cytoplasmic Antibody-associated Vasculitis
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DOI: 10.21873/invivo.13029
Abstract: Abstract Background/Aim: This study investigated a correlation between ex vivo interferon-gamma (IFN)-gamma production using IFN-gamma releasing assay (IGRA) and antineutrophil cytoplasmic antibody-associated vasculitis (AAV) activity assessed by Birmingham vasculitis activity score (BVAS) in AAV patients.… read more here.
Keywords: aav patients; vivo; gamma; ifn gamma ... See more keywords
Differential Virus-Specific IFN-Gamma Producing T Cell Responses to Marek’s Disease Virus in Chickens With B19 and B21 MHC Haplotypes
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DOI: 10.3389/fimmu.2021.784359
Abstract: Marek’s disease virus (MDV), the etiologic agent for Marek’s disease (MD), causes a deadly lymphoproliferative disease in chickens. Causes of the well-documented association between genetically defined lines of chicken and resistance to MD remain unknown.… read more here.
Keywords: cell responses; disease; ifn gamma; marek disease ... See more keywords