Innate immune response in patients with acute Zika virus infection
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DOI: 10.1007/s00430-019-00588-8
Abstract: Innate immunity receptors (Toll-like receptors/TLRs and RIG-like receptors/RLRs) are important for the initial recognition of Zika virus (ZIKV), modulation of protective immune response, and IFN-α and IFN-β production. Immunological mechanisms involved in protection or pathology… read more here.
Keywords: innate; rig; ifn; infection ... See more keywords
Escherichia coli infection activates the production of IFN-α and IFN-β via the JAK1/STAT1/2 signaling pathway in lung cells
Sign Up to like & getrecommendations! Published in 2021 at "Amino Acids"
DOI: 10.1007/s00726-021-03077-6
Abstract: Escherichia coli infections can result in lung injury, which may be closely linked to the induction of interferon secretion. The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is one of most important… read more here.
Keywords: production; jak1 stat1; ifn; ifn ifn ... See more keywords
Endothelial cell functions impaired by interferon in vitro: Insights into the molecular mechanism of thrombotic microangiopathy associated with interferon therapy.
Sign Up to like & getrecommendations! Published in 2018 at "Thrombosis research"
DOI: 10.1016/j.thromres.2018.01.039
Abstract: INTRODUCTION Interferon (IFN)-α and IFN-β approved for treatment of chronic hepatitis C viral infection and multiple sclerosis respectively have been linked to thrombotic microangiopathy (TMA) affecting renal function. Since the molecular mechanisms underlying this severe… read more here.
Keywords: ifn; endothelial cell; interferon; ifn ifn ... See more keywords
Role of interferons (IFNs) in the differentiation of T peripheral helper (Tph) cells 2. IFN-α and IFN-λ1 cooperatively contribute to the expansion of Tph cells in systemic lupus erythematosus.
Sign Up to like & getrecommendations! Published in 2022 at "International immunology"
DOI: 10.1093/intimm/dxac032
Abstract: Interleukin (IL)-21-producing T peripheral helper (Tph) cells are thought to contribute to extra-follicular B cell activation and play a pathogenic role in autoimmune diseases. In this study, we investigated relationship between Tph cells and interferons… read more here.
Keywords: ifn ifn; tph; role; tph cells ... See more keywords
The immune characterization of interferon‐β responses in tuberculosis patients
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DOI: 10.1111/1348-0421.12583
Abstract: We aimed to assess the immunoregulatory effects of IFN‐β in patients with tuberculous pleurisy. IFN‐β, IFN‐γ and IL‐17 expression levels were detected, and correlations among these factors in different culture groups were analyzed. Pleural fluid… read more here.
Keywords: neutralizing antibody; ifn; tuberculosis; expression ... See more keywords
Effective Interferon Lambda Treatment Regimen To Control Lethal MERS-CoV Infection in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00364-22
Abstract: Effective antiviral agents are urgently required to prevent and treat individuals infected with SARS-CoV-2 and other emerging viral infections. The COVID-19 pandemic has catapulted our efforts to identify, develop, and evaluate several antiviral agents. ABSTRACT… read more here.
Keywords: ifn ifn; antiviral agents; ifn; mers cov ... See more keywords
Identification of a Novel Interferon Lambda Splice Variant in Chickens
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Virology"
DOI: 10.1128/jvi.01743-22
Abstract: Interferons (IFNs) are critical soluble factors in the immune system, and are composed of 3 types (I, II, and III) that utilize different receptor complexes (IFN-αR1/IFN-αR2, IFN-γR1/IFN-γR2, and IFN-λR1/IL-10R2, respectively). Herein, we identified IFNL from… read more here.
Keywords: chifnl3a; ifn ifn; chicken; ifn ... See more keywords
Type I Interferons: Distinct Biological Activities and Current Applications for Viral Infection
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DOI: 10.1159/000495897
Abstract: The interferons (IFNs) are a primary defense against pathogens because of the strong antiviral activities they induce. IFNs can be classified into three groups: type I, type II and type III, according to their genetic,… read more here.
Keywords: type interferons; biological activities; ifn; ifn ifn ... See more keywords
IFN-α/IFN-λ responses to respiratory viruses in paediatric asthma
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DOI: 10.1183/13993003.00006-2017
Abstract: The letter by S. Baraldo and co-workers raises some interesting points. It is correct that we cannot exclude the possibility that interferon upregulation during the acute phase in asthmatics, though existent, is suboptimal if compared… read more here.
Keywords: responses respiratory; ifn; respiratory viruses; ifn responses ... See more keywords
A Positive Feedback Amplifier Circuit That Regulates Interferon (IFN)-Stimulated Gene Expression and Controls Type I and Type II IFN Responses
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.01135
Abstract: Interferon (IFN)-I and IFN-II both induce IFN-stimulated gene (ISG) expression through Janus kinase (JAK)-dependent phosphorylation of signal transducer and activator of transcription (STAT) 1 and STAT2. STAT1 homodimers, known as γ-activated factor (GAF), activate transcription… read more here.
Keywords: ifn; expression; ifn ifn; amplifier circuit ... See more keywords
Distinct Type I Interferon Subtypes Differentially Stimulate T Cell Responses in HIV-1-Infected Individuals
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.936918
Abstract: The expression of type I interferons (IFNs) is one of the immediate host responses during most viral infections. The type I IFN family consists of numerous highly conserved IFNα subtypes, IFNβ, and some others. Although… read more here.
Keywords: cell; ifn ifn; hiv infected; ifn ... See more keywords