Cordycepin Attenuates IFN-γ-Induced Macrophage IP-10 and Mig Expressions by Inhibiting STAT1 Activity in CFA-Induced Inflammation Mice Model
Sign Up to like & getrecommendations! Published in 2019 at "Inflammation"
DOI: 10.1007/s10753-019-01162-3
Abstract: Cordycepin, a natural derivative of adenosine, has been shown to exert pharmacological properties including anti-oxidation, antitumor, and immune regulation. It is reported that cordycepin is involved in the regulation of macrophage function. However, the effect… read more here.
Keywords: inflammation; cfa induced; model; ifn induced ... See more keywords
Antidepressant-like effects of 3-carboxamido seco-nalmefene (3CS-nalmefene), a novel opioid receptor modulator, in a rat IFN-α-induced depression model
Sign Up to like & getrecommendations! Published in 2018 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2017.08.016
Abstract: Patients receiving the cytokine immunotherapy, interferon-alpha (IFN-α) frequently present with neuropsychiatric consequences and cognitive impairments. Patients (25-80%) report symptoms of depression, including, anhedonia, irritability, fatigue and impaired motivation. Our lab has previously demonstrated treatment (170,000IU/kg… read more here.
Keywords: depression; 3cs nalmefene; ifn; ifn induced ... See more keywords
Oleic acid and oleoylethanolamide decrease interferon-γ-induced expression of PD-L1 and induce apoptosis in human lung carcinoma cells.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174116
Abstract: Inhibition of programmed death-ligand 1 (PD-L1) in cancer cells provides a reasonable avenue to prevent cancer progression. Although oleate is known to exert anti-cancer effects, its PD-L1 inhibitory effects have not been proven. This study… read more here.
Keywords: apoptosis; oleic acid; induced expression; ifn induced ... See more keywords
T-bet Transcription Factor Promotes Antibody-Secreting Cell Differentiation by Limiting the Inflammatory Effects of IFN-γ on B Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Immunity"
DOI: 10.1016/j.immuni.2019.04.004
Abstract: Although viral infections elicit robust interferon-γ (IFN-γ) and long-lived antibody-secreting cell (ASC) responses, the roles for IFN-γ and IFN-γ-induced transcription factors (TFs) in ASC development are unclear. We showed that B cell intrinsic expression of… read more here.
Keywords: transcription; antibody secreting; ifn; ifn induced ... See more keywords
The IFN-γ-induced immunoproteasome is suppressed in highly pathogenic porcine reproductive and respiratory syndrome virus-infected alveolar macrophages.
Sign Up to like & getrecommendations! Published in 2020 at "Veterinary immunology and immunopathology"
DOI: 10.1016/j.vetimm.2020.110069
Abstract: Highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) evades cytotoxic T lymphocyte (CTL) responses through interactions between viral Nsp1α and Nsp4 and β2 M heavy and light chains, respectively, of swine leukocyte antigen class… read more here.
Keywords: highly pathogenic; pathogenic porcine; porcine reproductive; ifn induced ... See more keywords
IFN-γ-induced ER stress impairs autophagy and triggers apoptosis in lung cancer cells
Sign Up to like & getrecommendations! Published in 2021 at "Oncoimmunology"
DOI: 10.1080/2162402x.2021.1962591
Abstract: ABSTRACT Interferon-gamma (IFN-γ) is a major effector molecule of immunity and a common feature of tumors responding to immunotherapy. Active IFN-γ signaling can directly trigger apoptosis and cell cycle arrest in human cancer cells. However,… read more here.
Keywords: expression; ifn induced; cancer cells; stress ... See more keywords
Bidirectional crosstalk between epithelial–mesenchymal plasticity and IFNγ-induced PD-L1 expression promotes tumour progression
Sign Up to like & getrecommendations! Published in 2022 at "Royal Society Open Science"
DOI: 10.1098/rsos.220186
Abstract: Epithelial-Mesenchymal Transition (EMT) and immunoevasion through upregulation of Programmed Death-Ligand 1 (PD-L1) are important drivers of cancer progression. While EMT has been proposed to facilitate PD-L1-mediated immunosuppression, the molecular mechanisms of their interaction remain obscure.… read more here.
Keywords: ifn induced; expression; ifn; induced expression ... See more keywords
HSP90 mediates IFNγ-induced adaptive resistance to anti-PD-1 immunotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-21-3917
Abstract: Constitutive or acquired resistance is a major problem limiting the clinical success of anticancer immunotherapies targeting the PD-1/PD-L1 interaction. Here, we report that the molecular chaperone HSP90 is a key mediator of IFNγ-induced adaptive immune… read more here.
Keywords: anti immunotherapy; induced adaptive; hsp90; ifn induced ... See more keywords
HDAC is indispensable for IFN-γ-induced B7-H1 expression in gastric cancer
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DOI: 10.1186/s13148-018-0589-6
Abstract: BackgroundB7 homolog 1 (B7-H1) overexpression on tumor cells is an important mechanism of immune evasion in gastric cancer (GC). Elucidation of the regulation of B7-H1 expression is urgently required to guide B7-H1-targeted cancer therapy. Interferon… read more here.
Keywords: ifn; induced expression; ifn induced; expression ... See more keywords
Identification of Interleukin1β as an Amplifier of Interferon alpha-induced Antiviral Responses
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DOI: 10.1371/journal.ppat.1008461
Abstract: The induction of an interferon-mediated response is the first line of defense against pathogens such as viruses. Yet, the dynamics and extent of interferon alpha (IFNα)-induced antiviral genes vary remarkably and comprise three expression clusters:… read more here.
Keywords: interferon alpha; induced antiviral; ifn induced; antiviral genes ... See more keywords
Paeoniflorin ameliorates interferon-alpha-induced neuroinflammation and depressive-like behaviors in mice
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.14160
Abstract: Long-term treatment with high-dose Interferon-alpha (IFN-α) has resulted in depression in 30–50% of the patients. Paeoniflorin may ameliorate the IFN-α-induced depression; however, the underlying mechanism is less studied. Here, we investigated the prophylactic antidepressant and… read more here.
Keywords: depression; paeoniflorin; ifn; like behaviors ... See more keywords