Dendritic cells Trigger IFN‐γ secretion by NK cells independent of IL‐12 and IL‐18
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149733
Abstract: It is commonly believed that IL‐12 produced by DCs in response to pathogens is the first signal that stimulates the production of IFN‐γ by NK cells. However, IL‐12 production by DCs in response to bacterial… read more here.
Keywords: dcs; ifn production; production; production cells ... See more keywords
Neonatal influenza‐specific effector CTLs retain elevated CD31 levels at the site of infection and have decreased IFN‐γ production
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.4a0518-191r
Abstract: The underlying mechanisms that regulate neonatal immune suppression are poorly characterized. CD31 (PECAM1) is highly expressed on neonatal lymphocytes and is a known modulator of TCR signaling. To further characterize the role of CD31 in… read more here.
Keywords: cd31; effector ctls; ifn production; ctls ... See more keywords
Klf10 favors Mycobacterium tuberculosis survival by impairing IFN‐γ production and preventing macrophages reprograming to macropinocytosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.4ma0422-288r
Abstract: Mycobacterium tuberculosis has developed diverse mechanisms to survive inside phagocytic cells, such as macrophages. Phagocytosis is a key process in eliminating invading pathogens; thus, M. tuberculosis efficiently disrupts phagosome maturation to ensure infection. However, inflammatory… read more here.
Keywords: tuberculosis survival; mycobacterium tuberculosis; klf10; tuberculosis ... See more keywords
4-1BB expression on MAIT cells is associated with enhanced IFN-γ production and depends on IL-2.
Sign Up to like & getrecommendations! Published in 2018 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2018.03.013
Abstract: The role of MAIT cells in immunity against Mycobacterium tuberculosis infection in humans is still largely unexplored. In this study, we investigated the functional role of 4-1BB on MAIT cells. We found that 4-1BB was… read more here.
Keywords: mait cells; expression mait; mait; ifn production ... See more keywords
DDX19 Inhibits Type I Interferon Production by Disrupting TBK1-IKKε-IRF3 Interactions and Promoting TBK1 and IKKε Degradation.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.01.029
Abstract: DExD/H-box helicase members are key receptors for recognizing viral nucleic acids, and they regulate retinoic acid-inducible gene I (RIG-I)-like receptor (RLR)-mediated type I interferon (IFN) production. Here, we report that the DExD/H-box helicase family member DExD/H-box… read more here.
Keywords: ddx19; ifn production; tbk1 ikk; production ... See more keywords
Combination of mesenchymal stem cells and FK506 prolongs heart allograft survival by inhibiting TBK1/IRF3-regulated-IFN-γ production.
Sign Up to like & getrecommendations! Published in 2021 at "Immunology letters"
DOI: 10.1016/j.imlet.2021.06.007
Abstract: Lifelong immunosuppression use presents many serious side effects to transplant recipients. Previous studies have shown that mesenchymal stem cells (MSC) regulate the progress of inflammation and protect allograft function. However, the benefits of MSC combined… read more here.
Keywords: heart; ifn production; tbk1 irf3; stem cells ... See more keywords
Hepatocytes paradoxically affect intrahepatic IFN-γ production in autoimmune hepatitis due to Gal-9 expression and TLR2/4 ligand release.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular immunology"
DOI: 10.1016/j.molimm.2020.05.014
Abstract: Hepatocytes are the targets in autoimmune hepatitis (AIH) that results in T cell-dependent liver injury. However, hepatocytes may also affect the hepatic T cells in AIH, but the underlying mechanisms are not fully understood. Here… read more here.
Keywords: intrahepatic ifn; tlr2 ligands; production; tlr2 ... See more keywords
Inhibition of mTOR suppresses IFNα production and the STING pathway in monocytes from systemic lupus erythematosus patients.
Sign Up to like & getrecommendations! Published in 2020 at "Rheumatology"
DOI: 10.1093/rheumatology/keaa060
Abstract: OBJECTIVE Increased IFNα is important in the pathogenesis of SLE. Plasmacytoid dendritic cells are considered the main producer of IFNα upon Toll-like receptor pathway activation. However, which cells produce IFNα following stimulation with cyclic GMP-AMP… read more here.
Keywords: expression; ifn production; ifn; sting pathway ... See more keywords
Pellino3 ligase negatively regulates Influenza B dependent RIG-I signaling through downregulation of TRAF3 mediated induction of the transcription factor IRF3 and IFNβ production.
Sign Up to like & getrecommendations! Published in 2023 at "Immunology"
DOI: 10.1111/imm.13637
Abstract: Viral infection activates the innate immune system, which recognizes viral components by a variety of pattern recognition receptors and initiates signaling cascades leading to the production of pro-inflammatory cytokines. To date, signaling cascades triggered after… read more here.
Keywords: pellino3; production; pellino3 ligase; ifn production ... See more keywords
PGD2/DP2 receptor activation promotes severe viral bronchiolitis by suppressing IFN-λ production
Sign Up to like & getrecommendations! Published in 2018 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aao0052
Abstract: RSV-induced prostaglandin D2 release contributes to disease severity by impairing IFN-λ production. RSV gives innate immunity the runaround Asthma can be exacerbated by pathogens such as respiratory syncytial virus (RSV); prostaglandin D2 (PGD2) is also… read more here.
Keywords: bronchiolitis; pgd2; production; rsv ... See more keywords
Inhibition of miR-200b-3p confers broad-spectrum resistance to viral infection by targeting TBK1
Sign Up to like & getrecommendations! Published in 2023 at "mBio"
DOI: 10.1128/mbio.00867-23
Abstract: ABSTRACT The host innate immune system’s defense against viral infections depends heavily on type I interferon (IFN-I) production. Research into the mechanisms of virus-host interactions is essential for developing novel antiviral therapies. In this study,… read more here.
Keywords: viral infection; mir 200b; infection; ifn production ... See more keywords