ERK inhibition aids IFN-β promoter activation during EV71 infection by blocking CRYAB degradation in SH-SY5Y cells.
Sign Up to like & getrecommendations! Published in 2023 at "Pathogens and disease"
DOI: 10.1093/femspd/ftad011
Abstract: Enterovirus 71 (EV71) can cause severe hand-foot-and-mouth disease with neurological complications. It has evolved multiple mechanisms to compromise the host type I interferon (IFN-I) response. In neuronal cells, EV71-mediated IFN-I antagonism may be associated with… read more here.
Keywords: promoter; sy5y cells; cryab; ifn promoter ... See more keywords
SARS-CoV-2 NSP12 Protein Is Not an Interferon-β Antagonist
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Virology"
DOI: 10.1128/jvi.00747-21
Abstract: Previous studies investigated the interaction between SARS-CoV-2 viral proteins and interferon signaling and proposed that several SARS-CoV-2 viral proteins, including NSP12, could suppress IFN-β activation. However, most of these results were generated from IFN-β promoter… read more here.
Keywords: protein; ifn promoter; luciferase; sars cov ... See more keywords