Identification of a New Cholesterol‐Binding Site within the IFN‐γ Receptor that is Required for Signal Transduction
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DOI: 10.1002/advs.202105170
Abstract: The cytokine interferon‐gamma (IFN‐γ) is a master regulator of innate and adaptive immunity involved in a broad array of human diseases that range from atherosclerosis to cancer. IFN‐γ exerts it signaling action by binding to… read more here.
Keywords: chol; signal transduction; cholesterol; receptor ... See more keywords
IFNγ receptor down‐regulation facilitates Legionella survival in alveolar macrophages
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DOI: 10.1002/jlb.4ma1019-152r
Abstract: Legionella pneumophila is an opportunistic human pathogen and causative agent of the acute pneumonia known as Legionnaire's disease. Upon inhalation, the bacteria replicate in alveolar macrophages (AM), within an intracellular vacuole termed the Legionella‐containing vacuole.… read more here.
Keywords: ifngr1 regulation; pneumophila; regulation; alveolar macrophages ... See more keywords
Type I IFN Receptor Signaling on B Cells Promotes Antibody Responses to Polysaccharide Antigens.
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DOI: 10.4049/jimmunol.2200538
Abstract: We previously reported monophosphoryl lipid A (MPL) and synthetic cord factor trehalose-6,6'-dicorynomycolate (TDCM) significantly increase Ab responses to T cell-independent type 2 Ags (TI-2 Ags) in a manner dependent on B cell-intrinsic TLR4 expression, as… read more here.
Keywords: cell; type ifn; signaling cells; ifn receptor ... See more keywords