IFN-γ regulates a complex pro-survival signal network in CLL.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of haematology"
DOI: 10.1111/ejh.13921
Abstract: BACKGROUND It is known that the microenvironmental cytokine IFN-γ provides a survival advantage for CLL cells. However, the mechanisms involved in this effect have not been properly investigated. METHODS Herein, we conducted a comprehensive screening… read more here.
Keywords: ifn regulates; complex pro; signal; regulates complex ... See more keywords
IFNγ regulates NAD+ metabolism to promote the respiratory burst in human monocytes
Sign Up to like & getrecommendations! Published in 2022 at "Blood Advances"
DOI: 10.1182/bloodadvances.2021005776
Abstract: Key Points IFNγ induces a highly oxidative metabolic phenotype with high rates of oxygen consumption by both mitochondria and NADPH oxidase. IFNγ induces a NAMPT-dependent, NAD+ salvage pathway that is required for complete induction of… read more here.
Keywords: ifn regulates; human monocytes; respiratory burst; burst human ... See more keywords