TRIM8 is required for virus-induced IFN response in human plasmacytoid dendritic cells
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aax3511
Abstract: TRIM8 and Pin1 oppositely control IRF7-induced interferon production. Plasmacytoid dendritic cells (pDCs) play a crucial role in antiviral innate immunity through their unique capacity to produce large amounts of type I interferons (IFNs) upon viral… read more here.
Keywords: ifn response; dendritic cells; plasmacytoid dendritic; trim8 ... See more keywords
Cellular sensing of extracellular purine nucleosides triggers an innate IFN-β response
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aba3688
Abstract: Metabolic analysis of ADA2-deficient cells shows that extracellular purine nucleosides trigger cellular innate immunity. Mechanisms linking immune sensing of DNA danger signals in the extracellular environment to innate pathways in the cytosol are poorly understood.… read more here.
Keywords: purine nucleosides; ifn response; dino; extracellular purine ... See more keywords
Ectopic expression of cGAS in Salmonella typhimurium enhances STING-mediated IFN-β response in human macrophages and dendritic cells
Sign Up to like & getrecommendations! Published in 2023 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-005839
Abstract: Background Interferon (IFN)-β induction via activation of the stimulator of interferon genes (STING) pathway has shown promising results in tumor models. STING is activated by cyclic dinucleotides such as cyclic GMP–AMP dinucleotides with phosphodiester linkages… read more here.
Keywords: mediated ifn; expression; ifn response; typhimurium ... See more keywords
Abstract B30: PTEN loss associates with type I and II IFN response in prostate cancer
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.tcm17-b30
Abstract: PTEN gene deletion and protein loss occurs in 20-30% of prostate cancer (PCa) cases and leads to poor disease outcome. Loss of the PTEN tumor suppressor gene activates the PI3 kinase pathway and also appears… read more here.
Keywords: prostate cancer; ifn response; cancer; pten loss ... See more keywords
Signaling pathways predisposing to chronic kidney disease progression.
Sign Up to like & getrecommendations! Published in 2020 at "JCI insight"
DOI: 10.1172/jci.insight.126183
Abstract: The loss of functional nephrons after kidney injury triggers the compensatory growth of the remaining ones to allow functional adaptation. However, in some cases, these compensatory events activate signaling pathways that lead to pathological alterations… read more here.
Keywords: signaling pathways; renal lesions; chronic kidney; ifn response ... See more keywords
DMO-CAP inhibits influenza virus replication by activating heme oxygenase-1-mediated IFN response
Sign Up to like & getrecommendations! Published in 2019 at "Virology Journal"
DOI: 10.1186/s12985-019-1125-9
Abstract: BackgroundAs a leading cause of respiratory disease, influenza A virus (IAV) infection remains a pandemic threat in annual seasonal outbreaks. Given the limitation of existing anti-influenza therapeutic drugs, development of new drugs is urgently required.… read more here.
Keywords: influenza virus; dmo cap; ifn response; cap ... See more keywords
The Long Non-coding RNA NRIR Drives IFN-Response in Monocytes: Implication for Systemic Sclerosis
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.00100
Abstract: TLR4 activation initiates a signaling cascade leading to the production of type I IFNs and of the downstream IFN-stimulated genes (ISGs). Recently, a number of IFN-induced long non-coding RNAs (lncRNAs) that feed-back regulate the IFN… read more here.
Keywords: ssc; response; ifn; type ifn ... See more keywords
Promoter Binding and Nuclear Retention Features of Zebrafish IRF Family Members in IFN Response
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.861262
Abstract: Interferon regulatory factors (IRFs) constitute a family of transcription factors that synchronize interferon (IFN) antiviral response through translocating to nucleus and binding to the promoters of IFN and IFN-stimulated genes (ISGs). Fish contain 11 IRF… read more here.
Keywords: family members; irf family; zebrafish irf; ifn response ... See more keywords
Low baseline IFN-γ response could predict hospitalization in COVID-19 patients
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.953502
Abstract: The SARS-CoV-2 infection has spread rapidly around the world causing millions of deaths. Several treatments can reduce mortality and hospitalization. However, their efficacy depends on the choice of the molecule and the precise timing of… read more here.
Keywords: predict hospitalization; ifn; ifn response; hospitalization ... See more keywords
Recombinant Human IFNα-2b Response Promotes Vaginal Epithelial Cells Defense against Candida albicans
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2017.00697
Abstract: Classical antifungal drugs have been subjected to restrictions due to drug toxicity, drug resistance, bioavailability, and detrimental drug interactions. Type I interferon (IFN) exerts direct distinct immunostimulatory or immunomodulatory actions; however, little is known regarding… read more here.
Keywords: recombinant human; epithelial cells; response; vaginal epithelial ... See more keywords
Inhibition of the IFN Response by Bluetongue Virus: The Story So Far
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2021.692069
Abstract: Bluetongue virus (BTV) is the prototypical orbivirus that belongs to the Reoviridae family. BTV infection produces a disease in ruminants, particularly in sheep, that results in economic losses through reduced productivity. BTV is transmitted by… read more here.
Keywords: bluetongue virus; inhibition ifn; ifn response; response ... See more keywords