Immune quorum sensing dictates IFN‐I response dynamics in human plasmacytoid dendritic cells
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Immunology"
DOI: 10.1002/eji.202350955
Abstract: Type I interferons (IFN‐Is) are key in fighting viral infections, but also serve major roles beyond antiviral immunity. Crucial is the tight regulation of IFN‐I responses, while excessive levels are harmful to the cells. In… read more here.
Keywords: quorum; response dynamics; immune quorum; ifn response ... See more keywords
Identification of Biomarkers for Response to Interferon in Chronic Hepatitis B Based on Bioinformatics Analysis and Machine Learning
Sign Up to like & getrecommendations! Published in 2025 at "Viral Immunology"
DOI: 10.1089/vim.2024.0091
Abstract: Interferon (IFN) is a pivotal agent against hepatitis B virus (HBV) in clinic, but there is a lack of accurate biomarkers to predict the response to IFN therapy in patients with chronic hepatitis B (CHB).… read more here.
Keywords: response; network; chronic hepatitis; ifn response ... See more keywords
TRIM8 is required for virus-induced IFN response in human plasmacytoid dendritic cells
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aax3511
Abstract: TRIM8 and Pin1 oppositely control IRF7-induced interferon production. Plasmacytoid dendritic cells (pDCs) play a crucial role in antiviral innate immunity through their unique capacity to produce large amounts of type I interferons (IFNs) upon viral… read more here.
Keywords: ifn response; dendritic cells; plasmacytoid dendritic; trim8 ... See more keywords
Cellular sensing of extracellular purine nucleosides triggers an innate IFN-β response
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aba3688
Abstract: Metabolic analysis of ADA2-deficient cells shows that extracellular purine nucleosides trigger cellular innate immunity. Mechanisms linking immune sensing of DNA danger signals in the extracellular environment to innate pathways in the cytosol are poorly understood.… read more here.
Keywords: purine nucleosides; ifn response; dino; extracellular purine ... See more keywords
Ectopic expression of cGAS in Salmonella typhimurium enhances STING-mediated IFN-β response in human macrophages and dendritic cells
Sign Up to like & getrecommendations! Published in 2023 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-005839
Abstract: Background Interferon (IFN)-β induction via activation of the stimulator of interferon genes (STING) pathway has shown promising results in tumor models. STING is activated by cyclic dinucleotides such as cyclic GMP–AMP dinucleotides with phosphodiester linkages… read more here.
Keywords: mediated ifn; expression; ifn response; typhimurium ... See more keywords
Abstract B30: PTEN loss associates with type I and II IFN response in prostate cancer
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.tcm17-b30
Abstract: PTEN gene deletion and protein loss occurs in 20-30% of prostate cancer (PCa) cases and leads to poor disease outcome. Loss of the PTEN tumor suppressor gene activates the PI3 kinase pathway and also appears… read more here.
Keywords: prostate cancer; ifn response; cancer; pten loss ... See more keywords
Signaling pathways predisposing to chronic kidney disease progression.
Sign Up to like & getrecommendations! Published in 2020 at "JCI insight"
DOI: 10.1172/jci.insight.126183
Abstract: The loss of functional nephrons after kidney injury triggers the compensatory growth of the remaining ones to allow functional adaptation. However, in some cases, these compensatory events activate signaling pathways that lead to pathological alterations… read more here.
Keywords: signaling pathways; renal lesions; chronic kidney; ifn response ... See more keywords
Expression signatures with specificity for type I and II IFN response and relevance for autoimmune diseases and cancer
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-025-06628-7
Abstract: Aberrant interferon signaling is a key element of various diseases, but resolving gene expression signatures that stem from different types of IFNs in tissue samples is still a challenge. Most published IFN signatures comprise genes… read more here.
Keywords: type; response; signature; expression ... See more keywords
DMO-CAP inhibits influenza virus replication by activating heme oxygenase-1-mediated IFN response
Sign Up to like & getrecommendations! Published in 2019 at "Virology Journal"
DOI: 10.1186/s12985-019-1125-9
Abstract: BackgroundAs a leading cause of respiratory disease, influenza A virus (IAV) infection remains a pandemic threat in annual seasonal outbreaks. Given the limitation of existing anti-influenza therapeutic drugs, development of new drugs is urgently required.… read more here.
Keywords: influenza virus; dmo cap; ifn response; cap ... See more keywords
Seasonal influenza a virus lineages exhibit divergent abilities to antagonize interferon induction and signaling
Sign Up to like & getrecommendations! Published in 2024 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1012727
Abstract: The circulation of seasonal influenza A viruses (IAVs) in humans relies on effective evasion and subversion of the host immune response. While the evolution of seasonal H1N1 and H3N2 viruses to avoid humoral immunity is… read more here.
Keywords: seasonal influenza; single cell; response; h3n2 viruses ... See more keywords
The difference in tumor immune microenvironment and IFN-γ response between solid and non-solid adenocarcinoma
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DOI: 10.21037/tlcr-2025-372
Abstract: Background Solid subtype adenocarcinomas have poor prognosis. Interferon-γ (IFN-γ) is a critical cytokine related to anti-tumor response in the tumor immune microenvironment. We aimed to identify the prognostic factors related to IFN-γ responsiveness. Methods A… read more here.
Keywords: gobp ifng; ifn response; solid subtype;