TMED2 Potentiates Cellular IFN Responses to DNA Viruses by Reinforcing MITA Dimerization and Facilitating Its Trafficking.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.11.048
Abstract: Mediator of IRF3 activation (MITA), also known as stimulator of interferon genes (STING), plays a vital role in the innate immune responses to cytosolic dsDNA. The trafficking of MITA from the ER to perinuclear vesicles is necessary… read more here.
Keywords: tmed2; dimerization facilitating; tmed2 potentiates; ifn responses ... See more keywords
Endogenous double-stranded Alu RNA elements stimulate IFN-responses in relapsing remitting multiple sclerosis.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2019.02.003
Abstract: Various sensors that detect double-stranded RNA, presumably of viral origin, exist in eukaryotic cells and induce IFN-responses. Ongoing IFN-responses have also been documented in a variety of human autoimmune diseases including relapsing-remitting multiple sclerosis (RRMS)… read more here.
Keywords: relapsing remitting; double stranded; multiple sclerosis; remitting multiple ... See more keywords
Transmissible gastroenteritis virus does not suppress IFN-β induction but is sensitive to IFN in IPEC-J2 cells
Sign Up to like & getrecommendations! Published in 2017 at "Veterinary Microbiology"
DOI: 10.1016/j.vetmic.2016.12.031
Abstract: Abstract Coronaviruses tend to efficiently evade innate immune sensing. Alpha-coronaviruses interfere with the type I interferon (IFN) response in various ways, ensuring the limited activation of IFN responses. Transmissible gastroenteritis virus (TGEV), an Alphacoronavirus genera… read more here.
Keywords: ifn; infection; transmissible gastroenteritis; ifn responses ... See more keywords
Lymphatic Type 1 Interferon Responses Are Critical for Control of Systemic Reovirus Dissemination
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Virology"
DOI: 10.1128/jvi.02167-20
Abstract: Type 1 interferons (IFN-1) are critical host responses to viral infection. However, the contribution of IFN-1 responses to control of viruses in specific cell and tissue types is not fully defined. ABSTRACT Mammalian orthoreovirus (reovirus)… read more here.
Keywords: dissemination; reovirus; ifn responses; spread ... See more keywords
Photosensitivity and type I IFN responses in cutaneous lupus are driven by epidermal-derived interferon kappa
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-213197
Abstract: Objective Skin inflammation and photosensitivity are common in patients with cutaneous lupus erythematosus (CLE) and systemic lupus erythematosus (SLE), yet little is known about the mechanisms that regulate these traits. Here we investigate the role… read more here.
Keywords: ifn; type ifn; cle; ifn responses ... See more keywords
IFN-α/IFN-λ responses to respiratory viruses in paediatric asthma
Sign Up to like & getrecommendations! Published in 2017 at "European Respiratory Journal"
DOI: 10.1183/13993003.00006-2017
Abstract: The letter by S. Baraldo and co-workers raises some interesting points. It is correct that we cannot exclude the possibility that interferon upregulation during the acute phase in asthmatics, though existent, is suboptimal if compared… read more here.
Keywords: responses respiratory; ifn; respiratory viruses; ifn responses ... See more keywords
Alcohol dependence promotes systemic IFN-γ and IL-17 responses in mice
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0239246
Abstract: Alcohol use disorder (AUD) is a chronic relapsing disorder characterized by an impaired ability to stop or control alcohol use despite adverse social, occupational, or health consequences. AUD is associated with a variety of physiological… read more here.
Keywords: responses mice; ifn responses; alcohol dependence; promotes systemic ... See more keywords
Naïve CD8 T cell IFNγ responses to a vacuolar antigen are regulated by an inflammasome-independent NLRP3 pathway and Toxoplasma gondii ROP5
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1008327
Abstract: Host resistance to Toxoplasma gondii relies on CD8 T cell IFNγ responses, which if modulated by the host or parasite could influence chronic infection and parasite transmission between hosts. Since host-parasite interactions that govern this… read more here.
Keywords: cd8 cell; cell ifn; ifn; gondii ... See more keywords
Consequences of sex differences in Type I IFN responses for the regulation of antiviral immunity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.986840
Abstract: The immune system protects us from pathogens, such as viruses. Antiviral immune mechanisms aim to limit viral replication, and must maintain immunological homeostasis to avoid excessive inflammation and damage to the host. Sex differences in… read more here.
Keywords: differences type; type ifn; antiviral immunity; ifn responses ... See more keywords
Ex Vivo Blockade of the PD-1 Pathway Improves Recall IFNγ Responses of HIV-Infected Persons on Antiretroviral Therapy
Sign Up to like & getrecommendations! Published in 2023 at "Vaccines"
DOI: 10.3390/vaccines11020211
Abstract: Despite antiretroviral therapy (ART), immune exhaustion persists in HIV infection and limits T cell responses to HIV or other pathogens. Moreover, HIV infection results in the loss of pre-existing immunity. Here, we investigated the effect… read more here.
Keywords: recall ifn; antiretroviral therapy; infected persons; hiv infected ... See more keywords