P163 Association between biomarkers and therapeutic pathway in patients with SLE
Sign Up to like & getrecommendations! Published in 2021 at "Rheumatology"
DOI: 10.1093/rheumatology/keab247.159
Abstract: Background/Aims SLE is heterogeneous in clinical presentation, underlying immunology, and response to therapy. Patients with severe or resistant disease receive cyclophosphamide or rituximab. Although effective, late use of these therapies entails cumulative damage. Emerging predictors… read more here.
Keywords: ifn score; none; includednot; association ... See more keywords
OP0124 In sle patients in sustained low disease activity, novel interferon assays predict flares and glucocorticoid requirements
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.3107
Abstract: Background Objectives of therapy in SLE are to maintain low disease activity and minimise glucocorticoid exposure. Disease activity is unpredictable with periods of low disease activity followed by flares. Once disease is controlled, there is… read more here.
Keywords: disease activity; low disease; activity; ifn score ... See more keywords
FRI0179 PREDICTION OF RESPONSE TO RITUXIMAB IN SLE USING A VALIDATED TWO-SCORE SYSTEM FOR INTERFERON
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.5750
Abstract: Background: Rituximab (RTX) is used for resistant SLE but clinical response varies. We previously validated two interferon-stimulated gene expression scores (IFN-Score-A and IFN-Score-B) that improved prediction of clinical outcomes in SLE. IFN-Score-A included most commonly… read more here.
Keywords: ifn score; response; score; none declared ... See more keywords
OP0091 A TWO-SCORE INTERFERON SIGNATURE AND MUSCULOSKELETAL IMAGING EXPLAIN THE ASSOCIATION BETWEEN INTERFERON AND ARTHRITIS IN SLE
Sign Up to like & getrecommendations! Published in 2020 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2020-eular.3564
Abstract: Interferon (IFN) signature is associated with disease activity and flare in SLE. We previously described two independent IFN gene expression scores; IFN Score A (the most commonly measured ISGs) and IFN Score B (less commonly… read more here.
Keywords: ifn score; interferon; signature; ifn ... See more keywords
OP0134 NOVEL INTERFERON GENE EXPRESSION SCORES PREDICT REFRACTORY SEVERE CUTANEOUS DISEASE FOLLOWING RITUXIMAB THERAPY IN SLE
Sign Up to like & getrecommendations! Published in 2021 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2021-eular.1098
Abstract: We developed and validated two continuous interferon-stimulated gene (ISG) expression scores (IFN-Score-A and IFN-Score-B) that predict clinical outcomes in SLE. IFN-Score-A includes ISGs typically present in a global interferon signature while IFN-Score-B includes additional ISGs… read more here.
Keywords: ifn score; none declared; bilag; disease ... See more keywords
POS0179 EXPLORING THE EFFECTS OF A TWO-SCORE INTERFERON SIGNATURE AND RESPONSES TO INTERFERON STIMULUS
Sign Up to like & getrecommendations! Published in 2021 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2021-eular.1100
Abstract: IFN Scores are increasingly important as biomarkers to stratify RMDs and select patients for interferon targeted therapies. Several studies have previously demonstrated that different sets of interferon stimulated genes (ISGs) have different clinical associations. We… read more here.
Keywords: expression; interferon signature; ifn score; score ... See more keywords
Type I interferon score is associated with the severity and poor prognosis in anti-MDA5 antibody-positive dermatomyositis patients
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1151695
Abstract: Objectives To investigate the clinical significance of the interferon (IFN) score, especially the IFN-I score, in patients with anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis (anti-MDA5+ DM). Methods We enrolled 262 patients with different autoimmune… read more here.
Keywords: score; ifn score; anti mda5; concentration ... See more keywords