FBXO11 amplifies type I interferon signaling to exert antiviral effects by facilitating the assemble of TRAF3–TBK1–IRF3 complex
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28655
Abstract: As the key component of host innate antiviral immunity, type I interferons (IFN‐Is) exert multiple antiviral effects by inducing hundreds of IFN‐stimulated genes. However, the precise mechanism involved in host sensing of IFN‐I signaling priming… read more here.
Keywords: tbk1; ifn signaling; traf3; tbk1 irf3 ... See more keywords
Recombinant MUC1-MBP fusion protein vaccine combined with CpG2006 induces antigen-specific CTL responses through cDC1-mediated cross-priming mainly regulated by type I IFN signaling in mice.
Sign Up to like & getrecommendations! Published in 2022 at "Immunology letters"
DOI: 10.1016/j.imlet.2022.04.002
Abstract: In this study, we explored the initiation and regulation mechanism of antigen-specific CTL responses induced by a novel cancer vaccine containing recombinant human mucin1-maltose-binding protein fusion protein (MUC1-MBP) and CpG2006. First, DC subsets were analyzed… read more here.
Keywords: specific ctl; ifn signaling; type ifn; ctl responses ... See more keywords
Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Cell stem cell"
DOI: 10.1016/j.stem.2021.03.002
Abstract: Age-related clonal hematopoiesis (CH) is a risk factor for malignancy, cardiovascular disease, and all-cause mortality. Somatic mutations in DNMT3A are drivers of CH, but decades may elapse between the acquisition of a mutation and CH,… read more here.
Keywords: dnmt3a; clonal hematopoiesis; ifn; infection ... See more keywords
Impaired IFNγ-Signaling and Mycobacterial Clearance in IFNγR1-Deficient Human iPSC-Derived Macrophages
Sign Up to like & getrecommendations! Published in 2018 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2017.11.011
Abstract: Summary Mendelian susceptibility to mycobacterial disease (MSMD) is caused by inborn errors of interferon gamma (IFNγ) immunity and is characterized by severe infections by weakly virulent mycobacteria. Although IFNγ is the macrophage-activating factor, macrophages from… read more here.
Keywords: signaling mycobacterial; mycobacterial clearance; impaired ifn; ifn ... See more keywords
Porcine circovirus 3 Cap inhibits type I interferon signaling through interaction with STAT2.
Sign Up to like & getrecommendations! Published in 2019 at "Virus research"
DOI: 10.1016/j.virusres.2019.197804
Abstract: Porcine circovirus 3 (PCV3) is a novel circovirus that is associated with porcine dermatitis and nephropathy syndrome, reproductive failure, and multi-systemic inflammation. The type I Interferon (IFN) signaling pathway is an important innate immune signaling… read more here.
Keywords: type interferon; porcine circovirus; circovirus; ifn signaling ... See more keywords
Inflammasome activation negatively regulates MyD88-IRF7 type I IFN signaling and anti-malaria immunity
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-07384-7
Abstract: The inflammasome plays a critical role in inflammation and immune responses against pathogens. However, whether or how inflammasome activation regulates type I interferon (IFN-I) signaling in the context of malaria infection remain unknown. Here we… read more here.
Keywords: irf7 type; myd88 irf7; inflammasome activation; ifn ... See more keywords
The osteopontin-CD44 axis in hepatic cancer stem cells regulates IFN signaling and HCV replication
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-31421-6
Abstract: Osteopontin (OPN) is involved in cell proliferation, migration, inflammation, and tumor progression in various tissues. OPN induces stemness by interacting with CD44, but the functional relevance of OPN-mediated interferon (IFN) signaling and hepatitis C virus… read more here.
Keywords: epcam cd44; ifn signaling; hcv replication; opn ... See more keywords
Lac water extract inhibits IFN-γ signaling through JAK2-STAT1-IRF1 axis in human melanoma
Sign Up to like & getrecommendations! Published in 2018 at "RSC Advances"
DOI: 10.1039/c8ra02955e
Abstract: Interferon-γ (IFN-γ) is a cytokine that plays an important role in the host defense of infectious diseases and in immune surveillance during tumor development; however, it has adverse effects in the pathogenesis of autoimmune diseases… read more here.
Keywords: water extract; stat1 irf1; lac water; ifn signaling ... See more keywords
Chromatin bridges, not micronuclei, activate cGAS after drug-induced mitotic errors in human cells.
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2103585118
Abstract: Mitotic errors can activate cyclic GMP-AMP synthase (cGAS) and induce type I interferon (IFN) signaling. Current models propose that chromosome segregation errors generate micronuclei whose rupture activates cGAS. We used a panel of antimitotic drugs… read more here.
Keywords: chromatin bridges; mitotic errors; micronuclei activate; chromatin ... See more keywords
FACT subunit SUPT16H associates with BRD4 and contributes to silencing of interferon signaling
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac645
Abstract: Abstract FACT (FAcilitates Chromatin Transcription) is a heterodimeric protein complex composed of SUPT16H and SSRP1, and a histone chaperone participating in chromatin remodeling during gene transcription. FACT complex is profoundly regulated, and contributes to both… read more here.
Keywords: ifn signaling; fact; brd4; supt16h ... See more keywords
CAGE sequencing reveals CFTR-dependent dysregulation of type I IFN signaling in activated cystic fibrosis macrophages
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.adg5128
Abstract: An intense, nonresolving airway inflammatory response leads to destructive lung disease in cystic fibrosis (CF). Dysregulation of macrophage immune function may be a key facet governing the progression of CF lung disease, but the underlying… read more here.
Keywords: ifn signaling; type ifn; dysregulation; cftr dependent ... See more keywords