Central Role of Macrophages and Nucleic Acid Release in Myasthenia Gravis Thymus
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DOI: 10.1002/ana.26590
Abstract: Myasthenia gravis (MG) is a neuromuscular disease mediated by antibodies against the acetylcholine receptor (AChR). The thymus plays a primary role in AChR‐MG and is characterized by a type I interferon (IFN) signature linked to… read more here.
Keywords: ifn signature; myasthenia gravis; central role; myasthenia ... See more keywords
The early local and systemic Type I interferon responses to ultraviolet B light exposure are cGAS dependent
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-64865-w
Abstract: Most systemic lupus erythematosus (SLE) patients are photosensitive and ultraviolet B light (UVB) exposure worsens cutaneous disease and precipitates systemic flares of disease. The pathogenic link between skin disease and systemic exacerbations in SLE remains… read more here.
Keywords: cgas; ifn signature; exposure; skin ... See more keywords
POS0078 CROSS-SECTIONAL ANALYSIS OF INTERFERON SIGNATURE IN PEDIATRIC SYSTEMIC LUPUS ERYTHEMATOSUS
Sign Up to like & getrecommendations! Published in 2021 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2021-eular.1956
Abstract: the role of interferon pathways in the pathogenesis of systemic lupus erythematosus (SLE) has been proven over the past years. Existing data suggest that interferon score (IFN I score) may serve as a useful marker… read more here.
Keywords: interferon; signature; interferon signature; ifn signature ... See more keywords
Distinct interferon signatures stratify inflammatory and dysimmune myopathies
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DOI: 10.1136/rmdopen-2018-000811
Abstract: Objective The role of interferons (IFN) in the pathophysiology of primary inflammatory and dysimmune myopathies (IDM) is increasingly investigated, notably because specific neutralisation approaches may constitute promising therapeutic tracks. In present work we analysed the… read more here.
Keywords: ifn signature; dysimmune myopathies; inflammatory dysimmune; ifn ... See more keywords
Assessment of type I interferon signatures in undifferentiated inflammatory diseases: A Japanese multicenter experience
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.905960
Abstract: Purpose Upregulation of type I interferon (IFN) signaling has been increasingly detected in inflammatory diseases. Recently, upregulation of the IFN signature has been suggested as a potential biomarker of IFN-driven inflammatory diseases. Yet, it remains… read more here.
Keywords: ifn signature; undifferentiated inflammatory; inflammatory diseases; type ifn ... See more keywords