STEM-09. INTRINSIC INTERFERON SIGNALING REGULATES THE CELL DEATH OF GLIOBLASTOMA STEM CELLS
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-oncology"
DOI: 10.1093/neuonc/noaa215.826
Abstract: Glioblastoma (GBM) is the most common, highly aggressive, and lethal primary brain tumor in adults. Interferon (IFN)-mediated signal transducer and activator of transcription 1 (STAT1) signaling contributes to various aspects of stemness, cell death, cytokine… read more here.
Keywords: ifn; ifn stat1; cell death; stat1 signaling ... See more keywords
NR4A1 mediates NK‐cell dysfunction in hepatocellular carcinoma via the IFN‐γ/p‐STAT1/IRF1 pathway
Sign Up to like & getrecommendations! Published in 2022 at "Immunology"
DOI: 10.1111/imm.13611
Abstract: Hepatocellular carcinoma (HCC) is one of the most fatal tumours worldwide and has a high recurrence rate. Nevertheless, the mechanism of HCC genesis remains partly unexplored, while the efficiency of HCC treatments remains limited. The… read more here.
Keywords: hepatocellular carcinoma; ifn stat1; dysfunction; stat1 irf1 ... See more keywords
Unique aspects of IFN‐γ/STAT1 signaling in neurons
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DOI: 10.1111/imr.13092
Abstract: The IFN‐γ/STAT1 immune signaling pathway impacts many homeostatic and pathological aspects of neurons, beyond its canonical role in controlling intracellular pathogens. Well known for its potent pro‐inflammatory and anti‐viral functions in the periphery, the IFN‐γ/STAT1… read more here.
Keywords: aspects ifn; ifn stat1; stat1 signaling; unique aspects ... See more keywords
Lineage Tracing and Single-Cell RNA Sequencing Reveal a Common Transcriptional State in Breast Cancer Tumor–Initiating Cells Characterized by IFN/STAT1 Activity
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/0008-5472.can-23-4022
Abstract: Coupling single-cell transcriptomics with tumor-initiating cell enrichment identified IFN response gene expression not previously reported in bulk RNA-sequencing–derived signatures and proposed IFN/STAT1 signaling as a candidate therapeutic target in breast cancer. read more here.
Keywords: cancer; single cell; rna sequencing; cell ... See more keywords
Aiolos promotes CXCR3 expression on Th1 cells via positive regulation of IFN-γ/STAT1 signaling
Sign Up to like & getrecommendations! Published in 2024 at "JCI Insight"
DOI: 10.1172/jci.insight.180287
Abstract: CD4+ T helper 1 (Th1) cells coordinate adaptive immune responses to intracellular pathogens, including viruses. Key to this function is the ability of Th1 cells to migrate within secondary lymphoid tissues, as well as to… read more here.
Keywords: stat1 signaling; th1; th1 cells; cxcr3 expression ... See more keywords
Tyrosine Kinase Inhibitors Stimulate HLA Class I Expression by Augmenting the IFNγ/STAT1 Signaling in Hepatocellular Carcinoma Cells
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.707473
Abstract: Combination treatment with tyrosine kinase inhibitors (TKIs) and immunotherapies has shown efficacy in the treatment of multiple cancers, but the immunomodulatory effect of TKIs on the tumor cell phenotype remains unknown in hepatocellular carcinoma (HCC).… read more here.
Keywords: kinase inhibitors; kinase; ifn stat1; expression ... See more keywords
Intrinsic Interferon Signaling Regulates the Cell Death and Mesenchymal Phenotype of Glioblastoma Stem Cells
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13215284
Abstract: Simple Summary Interferon signaling is mostly studied in the context of immune cells. However, its role in glioma cancer cells is unclear. This study aimed to investigate the role of cancer-cell-intrinsic IFN signaling in tumorigenesis… read more here.
Keywords: ifn; ifn signaling; ifn stat1; stat1 signaling ... See more keywords