Delivery of Anti-IFNAR1 shRNA to Hepatic Cells Decreases IFNAR1 Gene Expression and Improves Adenoviral Transduction and Transgene Expression
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Biotechnology"
DOI: 10.1007/s12033-021-00408-6
Abstract: Chronic liver injury leads to advanced fibrosis, cirrhosis, and hepatocellular carcinoma. Genetical cell treatment related to the use of adenovirus (Ads) has proven to be beneficial and efficient in the recovery of hepatic diseases. Nevertheless,… read more here.
Keywords: ifnar1; transgene expression; gene expression; expression ... See more keywords
Type I interferon suppresses tumor growth through activating the STAT3-granzyme B pathway in tumor-infiltrating cytotoxic T lymphocytes
Sign Up to like & getrecommendations! Published in 2019 at "Journal for Immunotherapy of Cancer"
DOI: 10.1186/s40425-019-0635-8
Abstract: BackgroundType I interferons (IFN-I) have recently emerged as key regulators of tumor response to chemotherapy and immunotherapy. However, IFN-I function in cytotoxic T lymphocytes (CTLs) in the tumor microenvironment is largely unknown.MethodsTumor tissues and CTLs… read more here.
Keywords: ifnar1; tumor infiltrating; ctls; mice ... See more keywords
Specific activation of embryonic IFNAR1 and endometrial IFNAR2 induced by embryonic IFNτ directs normal uterine fate for bovine early implantation.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of reproductive immunology"
DOI: 10.21203/rs.3.rs-1297654/v1
Abstract: Interferon-tau (IFNτ), as an antiluteolytic factor secreted by trophoderm during the pregnancy of ruminants, actually functions by activating the IFNτ receptor 1 (IFNAR1) and IFNτ receptor 2 (IFNAR2). However, it has not been clearly understood… read more here.
Keywords: ifnar2; bovine; ifn; ifnar1 ifnar2 ... See more keywords
Construction of an Immune Escape-Related Signature in Clear Cell Renal Cell Carcinoma and Identification of the Relationship between IFNAR1 and Immune Infiltration by Multiple Immunohistochemistry
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers15010169
Abstract: Simple Summary This research found that a higher immune escape score was significantly correlated with a shorter survival time. Meanwhile, through the validation of the external cohort and the correlation analysis of the immune microenvironment,… read more here.
Keywords: infiltration; cell; ccrcc; immune escape ... See more keywords