PIM1 Attenuates Innate Immunity to Foster Coronavirus Replication through Ubiquitin Ligase β‐TrCP‐Mediated IFNAR1 Degradation
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DOI: 10.1002/advs.202503487
Abstract: Virus infection stimulates proto‐oncoprotein PIM1 kinase expression, but its importance and the biological functions of this process are poorly understood. Herein, PIM1 promotes IFNAR1 degradation to attenuate cellular innate immunity during human coronavirus HCoV‐OC43 infection.… read more here.
Keywords: innate immunity; replication; pim1; ifnar1 degradation ... See more keywords
IFNAR1 Degradation: A New Mechanism for Tumor Immune Evasion?
Sign Up to like & getrecommendations! Published in 2017 at "Cancer cell"
DOI: 10.1016/j.ccell.2017.01.012
Abstract: Type I interferons have been shown to play a major role in anti-cancer immunity. In this issue of Cancer Cell, Katlinski et al. describe tumor-induced degradation of type I interferon receptor IFNAR1 chain as a new… read more here.
Keywords: immune evasion; ifnar1 degradation; mechanism; tumor ... See more keywords