Macrophage Depletion Reactivates Fecal Virus Shedding following Resolution of Acute Hepatitis A in Ifnar1–/– Mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.01496-22
Abstract: HAV RNA persists in the liver of infected chimpanzees and interferon receptor-deficient Ifnar1−/− mice for many months after neutralizing antibodies appear, virus has been cleared from the blood, and fecal virus shedding has terminated. Here,… read more here.
Keywords: viral rna; rna; fecal virus; ifnar1 mice ... See more keywords
IRF3-mediated pathogenicity in a murine model of human hepatitis A
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1009960
Abstract: HAV-infected Ifnar1-/- mice recapitulate many of the cardinal features of hepatitis A in humans, including serum alanine aminotransferase (ALT) elevation, hepatocellular apoptosis, and liver inflammation. Previous studies implicate MAVS-IRF3 signaling in pathogenesis, but leave unresolved… read more here.
Keywords: hav; irf3; irf3 mediated; ifnar1 mice ... See more keywords