Specific activation of embryonic IFNAR1 and endometrial IFNAR2 induced by embryonic IFNτ directs normal uterine fate for bovine early implantation.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of reproductive immunology"
DOI: 10.21203/rs.3.rs-1297654/v1
Abstract: Interferon-tau (IFNτ), as an antiluteolytic factor secreted by trophoderm during the pregnancy of ruminants, actually functions by activating the IFNτ receptor 1 (IFNAR1) and IFNτ receptor 2 (IFNAR2). However, it has not been clearly understood… read more here.
Keywords: ifnar2; bovine; ifn; ifnar1 ifnar2 ... See more keywords
Synthetic mimetics assigned a major role to IFNAR2 in type I interferon signaling
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.947169
Abstract: Type I interferons (IFNs) are potent inhibitors of viral replication. Here, we reformatted the natural murine and human type I interferon-α/β receptors IFNAR1 and IFNAR2 into fully synthetic biological switches. The transmembrane and intracellular domains… read more here.
Keywords: type; ifnar2; gfp mcherry; ifnar1 ifnar2 ... See more keywords
Polymorphisms in ACE1, TMPRSS2, IFIH1, IFNAR2, and TYK2 Genes Are Associated with Worse Clinical Outcomes in COVID-19
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DOI: 10.3390/genes14010029
Abstract: Although advanced age, male sex, and some comorbidities impact the clinical course of COVID-19, these factors only partially explain the inter-individual variability in disease severity. Some studies have shown that genetic polymorphisms contribute to COVID-19… read more here.
Keywords: ifnar2; risk; polymorphisms ace1; ifih1 ... See more keywords