S100A9 up-regulated by IFNGR signaling blockade functions as a novel GvHD suppressor without compromising GvL in mice.
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2021012687
Abstract: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment for both malignant and nonmalignant hematologic disorders. However, graft-versus-host disease (GvHD) and malignant relapse limit its therapeutic success. We previously demonstrated that blockade of interferon-gamma… read more here.
Keywords: ifngr signaling; s100a9; gvhd; gvhd suppressor ... See more keywords